Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria

Clarke, Gerard; Cryan, John F.; Dinan, Timothy G.; Quigley, Eamonn Martin

doi:10.1111/j.1365-2036.2011.04965.x

Cited by 184 publications

(130 citation statements)

References 102 publications

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“…Similar to the findings of Moayyedi et al, Clarke and coworkers also showed that despite significant studies heterogeneity in their analysis of 42 randomized-controlled trials, 34 studies reported beneficial effects on at least one pre-specified endpoint including improvement in abdominal pain/discomfort, improvement on abdominal bloating/distension compared to placebo [69]. Both Bifidobacteria and Lactobacilli were found effective in ameliorating IBS symptoms, while the beneficial effects of the multispecies lactic acid bacteria preparations, including the multi-strain preparation VSL#3, were less pronounced.…”

Section: Probioticssupporting

confidence: 64%

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Rai¹,

Rai²

2017

Functional Food - Improve Health Through Adequate Food

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The identiication of bioactive food components and understanding their role as adjunct therapeutic agents in disease management and prevention has become a signiicant area of research. Accumulating evidence suggests a link between certain bioactive food components and health outcomes, for example, lutein and zeaxanthin for visual performance and delaying age-related macular degeneration, probiotics for gastrointestinal outcomes related to irritable bowel syndrome or prebiotics for its potential programming of the microbiome in early life to inluence later life outcomes.. This rapidly developing science has triggered discussions to determine if public health recommendations can be made on bioactive foods. However, regulatory guidance is necessary to guide the development the science, it's consideration for public health policy and the communication thereof to both healthcare professionals and consumers. This chapter will focus on the clinical and basic science supporting a role for lutein and pre-and probiotics in modulating several aspects of human health, including the gut microbiome through the human lifecycle. Opportunities to translate the science to consumers in a meaningful and accurate way will also be highlighted along with the regulatory landscape to shape the testing, communication and commercialization of these bioactives.

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Section: Probioticssupporting

confidence: 64%

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Rai¹,

Rai²

2017

Functional Food - Improve Health Through Adequate Food

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“…66 More than 40 probiotic intervention studies performed in IBS patients have been published and recently reviewed. [67][68][69][70] In most studies, a strong placebo effect was observed, underscoring the important role that subjective psychological factors play in the response to treatment in these patients. Nevertheless, many of these studies have demonstrated efficacy in improving functional GI symptoms in IBS patients.…”

Section: Conclusion and Future Researchmentioning

confidence: 99%

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology

Saulnier¹,

et al. 2013

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The brain-gut axis allows bidirectional communication between the central nervous system (CNS) and the enteric nervous system (ENS), linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent experimental work suggests that the gut microbiota have an impact on the brain-gut axis. A group of experts convened by the International Scientific Association for Probiotics and Prebiotics (ISAPP) discussed the role of gut bacteria on brain functions and the implications for probiotic and prebiotic science. The experts reviewed and discussed current available data on the role of gut microbiota on epithelial cell function, gastrointestinal motility, visceral sensitivity, perception and behavior. Data, mostly gathered from animal studies, suggest interactions of gut microbiota not only with the enteric nervous system but also with the central nervous system via neural, neuroendocrine, neuroimmune and humoral links. Microbial colonization impacts mammalian brain development in early life and subsequent adult behavior. These findings provide novel insights for improved understanding of the potential role of gut microbial communities on psychological disorders, most particularly in the field of psychological comorbidities associated with functional bowel disorders like irritable bowel syndrome (IBS) and should present new opportunity for interventions with pro-and prebiotics.

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“…Clinicians dealing with this challenge may wish to consider the growing evidence of the importance microbial ecology in human mental and general health, particularly in relation to microbes that: (a) generate the neuroprotective short-chain fatty acids n-butyrate, acetate, and propionate as by-products of their own metabolism [62]; (b) synthesise Menaquinones (vitamin K2) which play an important role in bone remineralisation and calcium regulation – of particular relevance to osteopenia in the elderly [63]; (c) produce indoles such as indolamine-2,3-dioxygenase, which act as catalysing enzymes in tryptophan synthesis, with corresponding beneficial effects on the gut epithelium, but also on serotonin synthesis [64,65]. They might also wish to consider the bacterial species that have been found to upregulate neurotransmitters and neurotransmitter precursors, including GABA, Dopamine, 5HT, and acetylcholine – of particular relevance to mental illness and to neurodegenerative diseases such as Alzheimer’s and Parkinson’s [66].…”

Section: Institutional Coprophagia Todaymentioning

confidence: 99%

Coprophagy in nineteenth-century psychiatry

Moore

2018

Microbial Ecology in Health and Disease

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This paper shows how Austrian psychiatrists of the 1870s developed the first pathological accounts of institutional coprophagia, examining how they related the behaviour to mental illness and dementia. These ideas about coprophagia contrasted dramatically to the long European pharmacological tradition of using excrement for the treatment of a wide range of health conditions. Recent medical scholarship on institutional coprophagia is also reviewed here, with a novel hypothesis proposed about why some patients in long-term care resort to the behaviour in institutions where there is little opportunity for healthy human–microbe interactions.

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Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria

Cited by 184 publications

References 102 publications

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology

Coprophagy in nineteenth-century psychiatry

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