Review and Expectation of Application of the Mechanism of the Biological Immune System in Work Safety Management

Qing-guang, Chen; Duan, Weili; Chen, Guohua; Han, Guilai

doi:10.1016/j.proeng.2011.04.621

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Such analogues are also found in the AIS literature. For example, Qingguang et al 64 matched risk management processes to immune mechanisms, such as risk identification to self/ nonself discrimination and risk treatment to immune response. In a similar line of thinking, Sarkheyli 65 proposed a new risk management framework with three lines of defence that mimics the innate (generic) and adaptive (specific) immune responses.…”

Section: Bio-inspired Framework For Dramentioning

confidence: 99%

Developing next generation marine risk analysis for ships: Bio-inspiration for building immunity

Ventikos

Louzis

2022

Proceedings of the Institution of Mechanical Engineers, Part O:

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Research on autonomous ships has led to several ideas about how they could be operated in terms of level of automation and human presence. However, all seem to point towards systems that will be more complex due to issues such as the tighter integration with software and the interactions with humans-in-the-loop. These ships will likely be completely different compared to conventional ones, which puts into question the usefulness of our current understanding of risk and how it is managed for ensuring safe operation. By a critical review of the literature, this paper highlights the need for advanced methods that will combine machine learning and simulation for dynamically assessing risk in a life cycle context and effectively transferring acquired operational knowledge back to the design phase. The main objective of this paper is to describe a novel life cycle risk framework for developing algorithms inspired by the biological immune system, which provides lifetime protection from harmful pathogens. This framework can be used to construct machine learning algorithms for dynamic risk monitoring and adaptive risk control that address different types of risk, while enabling faster future response to previously unencountered risks and operational feedback to design through learning. We demonstrate the feasibility of our approach in a specific maritime context with a case study on collision risk identification. Considering the lack of experience for autonomous ships, the benefit of our immune-inspired approach is that it departs from the classic risk scenario concept and that it does not rely on safety performance data for identifying risk factors and training the algorithms. We suggest this framework is particularly suitable for autonomous ships with high levels of autonomy, although applicable to conventional ships as well, as it can contribute to empowering them with risk awareness and the capability to deal with any risk environment.

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Section: Bio-inspired Framework For Dramentioning

confidence: 99%

Developing next generation marine risk analysis for ships: Bio-inspiration for building immunity

Ventikos

Louzis

2022

Proceedings of the Institution of Mechanical Engineers, Part O:

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“…The noise prediction can be carried out only when the statistically steady-state solution was acquired in large eddy simulation of the unsteady flow field [5] . FW-H equation based on Lighthill acoustic analogy theory is used to simulate sound production and dissemination when the noise is predicted.…”

Section: Models and Numerical Simulationmentioning

confidence: 99%

“…6 The Velocity Field Distribution of The Blade Tip Torus (radius=0.039m) Analysis for Fan Noise. Eddy current is one of the main factors to generate broadband noise in fan steady flow field.And the effective eddy currents mainly locate in the tip clearance [5] ,which directly impact the intensity of broadband noise. Broadband noise from the fan must be considered due to the wide distribution on various bands.Meanwhile, the power spectral density can better reflect the energy distribution of aerodynamic noise on various bands, so which is very effective to analyze the trend of noise distribution of the different fan models.…”

mentioning

confidence: 99%

Effect of Blade Numbers on Aerodynamic Performance and Noise of Small Axial Flow Fan

Zhang

Jin

2011

AMR

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To more fully explore the effect of blade numbers on aerodynamic performance and noise of small axial flow fan, some solutions are adopted to obtain the parameters’ distribution of the flow field.Firstly, the standard k-ε turbulence model is used to calculate the steady flow field of six different fan blades(such as 5,7,9,11,13,15) , and the SIMPLE algorithm is applied to couple vecolity and pressure. Secondly, the large eddy simulation in conjunction with the FH-W noise model are used to compute the unsteady flow field and noise. Finally, the experimental results verify that the calculation methods of steady flow field and unsteady flow field are correct. The conclusions show: (1)Total pressure and efficiency generally maintain the trend of firstly increasing and then decreasing with increasing the blade numbers, and it is the greatest when fan blade number is 11. The flow rate coupled with the maximum efficiency has never changed with increasing the blade numbers. (2)With the increasing blades, overall sound pressure level of the aerodynamic noise is gradually decreasing near the outlet of fan tip, while it is firstly decreasing and then increasing before decreasing again 1 meter away from the central axis of the impeller along the outlet. When fan blade number is 11, overall sound pressure level of the aerodynamic noise is the greatest.

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The impacts of treatment with newly developed probiotic versus phaleria macrocarpa leaves extract on the histological features in immunocompromised New Zealand white rabbits

Saleh

Zain

Ibrahim

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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This research aimed to examine the possible effectiveness of treatment with a freshly formulated new probiotic versus Phaleria macrocarpa leaves extract indicated by the histopathological changes occurred to the colon of the immunocompromised New Zealand White (NZW) rabbits. The study included 40 rabbits, divided into 4 groups. Three of the groups were fed with the immunosuppressive medication (azathioprine, 500 mg/kg/day) to be immunocompromised, Group B was treated with P. macrocarpa extract, Group Ctreated with our developed probiotic, and the group D left untreated as a positive control, Group A regarded as control negative. The duration of immunocompromising drug induction was set as 14 days; and the period of treatment was set for another 14 days. Distinctly, the treated rabbits were showing improvements of healing processes compared to non-treated, where the signs of lack of normal mucous folds, different degrees of mucosal edema and congestion, submucosal hemorrhage, accumulative score of gross colon morphology and major severe lesions of the colon tissue of the non-treated were significantly improved in the probiotic treated, as well as, P. macrocarpa treated groups. As a conclusion, the results indicated that uptake of the formulated probiotic could strengthen rabbits’ immune responses of the immunoco-mpromised rabbits significantly (both the specific and non-specific responses) and retain the weakened colon tissues (caused by the immunosuppressant drug). These findings are recommended to be used in future for development of promising commercial supplements to mitigate the medical risks that comes with immunosuppressant medications currently given to animals or human patients under certain circumstances.

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Review and Expectation of Application of the Mechanism of the Biological Immune System in Work Safety Management

Cited by 5 publications

References 11 publications

Developing next generation marine risk analysis for ships: Bio-inspiration for building immunity

Developing next generation marine risk analysis for ships: Bio-inspiration for building immunity

Effect of Blade Numbers on Aerodynamic Performance and Noise of Small Axial Flow Fan

The impacts of treatment with newly developed probiotic versus phaleria macrocarpa leaves extract on the histological features in immunocompromised New Zealand white rabbits

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