Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria

Cao, Zhiqiang; Mi, Luo; Mendiola, Jose; Ella‐Menye, Jean‐Rene; Zhang, Lei; Xue, Hong; Jiang, Shaoyi

doi:10.1002/ange.201106466

Cited by 49 publications

(71 citation statements)

References 18 publications

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“…Hence, addressing the open merocyanine form as "zwitterionic" is misleading, as it typically shows a strong dipole moment only but does not dispose of ionic sites. [128,445]; (b) via bisulfite-aldehyde addition [425,446]; (c) and (d) via addition of CO 2 to amidines [441] or carbenes [442,443], respectively. Redox reactions offer better chances for implementing a switching process, though reversible organic redox systems, for which the oxidized as well as the reduced states are stable under aqueous conditions, are rare.…”

Section: Responsive Polyzwitterionsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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Abstract:The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples.

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Section: Responsive Polyzwitterionsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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“…However, the mechanical properties of carboxybetaine structures with a methacrylate backbone were improved with the introduction of hydroxyl groups to lactone rings that resulted in the formation of intermolecular hydrogen-bonding. [101] poly (56) The reversible switch was reported on the surface of poly(45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP. The structure contained a quaternary amine lactone H + (TFA, HAc) (polymer brushes) [98] 14 backbone imparted a marked hydrophilic performance to the carboxybetaine polymer compared with the methacrylate-based carboxybetaine polymer, which resulted in an improvement in the elasticity and tensile strength of the polymers due to the formation of hydrogen-bonding.…”

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

“…[101] poly (56) The reversible switch was reported on the surface of poly(45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP. The structure contained a quaternary amine lactone H + (TFA, HAc) (polymer brushes) [98] 14 backbone imparted a marked hydrophilic performance to the carboxybetaine polymer compared with the methacrylate-based carboxybetaine polymer, which resulted in an improvement in the elasticity and tensile strength of the polymers due to the formation of hydrogen-bonding. However, the mechanical properties of carboxybetaine structures with a methacrylate backbone were improved with the introduction of hydroxyl groups to lactone rings that resulted in the formation of intermolecular hydrogen-bonding.…”

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

“…However, the mechanical properties of carboxybetaine structures with a methacrylate backbone were improved with the introduction of hydroxyl groups to lactone rings that resulted in the formation of intermolecular hydrogen-bonding. The reversible switch was reported on the surface of poly (45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP. The structure contained a quaternary amine lactone poly (55) H + (modified dextran) [101] poly (56) The reversible switch was reported on the surface of poly (45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP.…”

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

See 2 more Smart Citations

Switchable Materials Containing Polyzwitterion Moieties

2015

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Abstract:In recent decades, the design and construction of smart materials capable of switching into a polyzwitterionic state by an external trigger have been intensively pursued. Polyzwitterionic states have unique antifouling and surface properties and external triggers, such as pH, light, ions, electric field and CO 2 , cause significant changes in materials with regard to overall charge, ionic strength and wettability. This survey highlights current progress in the irreversible as well as the reversible switching process involving polyzwitterionic moieties, which can, in turn, be applied to studying the interaction of various interfaces with biological species as protein, DNA, bacteria or platelets and also for advanced use.

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Stimuli‐Responsive Surfaces in Biomedical Applications

Pranzetti¹,

Preece²,

Mendes³

2013

Intelligent Stimuli‐Responsive Materials

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Nature provides mechanisms that are able to dynamically control specific and nonspecific interactions between cells and biological surfaces [1,2]. Scientists have long tried to reproduce these dynamic biological events and have recently made an important step in that direction by creating artificial stimuli-responsive surfaces [3][4][5][6][7]. These smart substrates present modulatory surface properties that are able to respond to external chemical/biochemical [8][9][10][11][12], thermal [13][14][15], electrical [16][17][18][19][20], and optical stimuli [21][22][23][24][25][26][27][28][29][30][31]. Due to their dynamic nature such substrates are very appealing for applications in the biomedical field [32]. Progress to date has led to control over biomolecule activity [33] and immobilization of a diverse array of proteins, including enzymes [34] and antibodies [35]. These prior achievements have encouraged researchers to take the challenge of using dynamic surfaces to modulate larger and more complex systems, such as bacteria [36] and mammalian cells [37].Achieving control over surface properties could provide new insights in the understanding of cell behavior and can offer distinct benefits with regard to the development of medical devices. For instance, the modulation of cell attachment and detachment could lead to the prevention of unwanted bacteria fouling on implants, reducing the risk of infections and rejection [38][39][40][41][42]. Furthermore, dynamic surfaces able to present on demand regulatory signals to a cell could provide unprecedented opportunities in studies of cell responses in real-time. Cells in tissues adhere to and interact with their extracellular environment via specialized cell-cell and cell-extracellular

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Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria

Cited by 49 publications

References 18 publications

Structures and Synthesis of Zwitterionic Polymers

Structures and Synthesis of Zwitterionic Polymers

Switchable Materials Containing Polyzwitterion Moieties

Stimuli‐Responsive Surfaces in Biomedical Applications

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