Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

“…To achieve this goal, continuous efforts have been dedicated to the development of stimuli-responsive nanoplatforms. [2] Environmental stimuli that were exploited include pH, [3] temperature, [4] enzymatic expression, [5] redox reaction, [6] and light. [7] Among these activating signals, pH triggers belong to the most extensively studied stimuli based on two types of differences in pH: a) pathological (e.g.…”

“…Illustration of tunable, ultra-pH-responsive properties of pHAM nanoprobes. a) Representative fluorescence images of different nanoprobe solutions (6,3,4) at the same polymer concentration (0.1 mg mL À1 ) but different pH values. A narrow pH response is observed for each nanoprobe at different transition pH values.…”

Dual Stimuli‐Responsive Polymeric Micelles Exhibiting “AND” Logic Gate for Controlled Release of Adriamycin

“…[12] This large difference has been exploited for disulfide-triggered delivery in biotherapeutics. [6] A variety of DDS, including polymeric micelles, [13] nanogels [14] and nanoparticles [15] have been prepared base on this strategy. For example, Sun et al prepared disulfide linked polymeric micelles as drug carriers for drug controlled release.…”

A Facile Strategy for Constructing Boron‐Rich Polymer Nanoparticles via a Boronic Acid‐Related Reaction

“…[5][6][7][8] They can be prepared by the partial hydrophobic modifications of biopolymers that result in amphiphilic character and consequently induce the self-assembly of biopolymers into NPs. [9][10] Nonetheless, the covalent modification processes are usually quite complicated and time consuming and thus it is virtually inconvenient to control the We present here a facile strategy for constructing Dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) through a radical polymerization of the monomer 3-acrylamidophenylboronic acid (APBA) bound by dextran via a boronic acid-diol reaction in aqueous solution. The synthesized Dextran-PAPBA NPs are stable in a wide pH range.…”