Reversibles Azathioprin assoziiertes dysmyeloproliferatives Syndrom nach Nierenallotransplantation

Bammatter, F.; Binswanger, U; Fehr, J

doi:10.1007/bf01726672

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…12 Üç böbrek allotransplant alı-cısında, immünsupresyon için azatioprinden siklosporin A'ya geçildiğinde tama yakın geri dö-nüşümlü olan dismiyeloproliferatif sendrom geliş-miştir. 13 Prischl ve ark. 20 yıllık süreçte bir böbrek nakli alıcısında iki ayrı göğüs kanseri ve üroepitel-yal karsinom geliştiğini ve ayrıca önceki kanser kemoterapisine sekonder MDS gelişip bunun 19 ay sonra akut lösemiye dönüştüğünü bildirmiştir.…”

Section: Discussionunclassified

Myelodysplastic Syndrome After Kidney Transplantation: Case Report

Sayilar¹,

Orhan²,

Ayar³

et al. 2014

Turkiye Klinikleri J Nephrol

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ransplant hastalarda, immünsupresif tedavi, bozulmuş immün sistem ve virüslerin onkojenik etkileri nedeniyle de novo kanser gelişim riski yüksektir. Nakil sonrası gelişen maligniteler içerisinde lenfoproliferatif hastalık ve cilt kanserleri ilk sırada yer alırken klonal kök hücreden köken miyelodisplastik sendrom (MDS) oldukça nadir görülmektedir. MDS, ileri yaşta ve erkeklerde görülen, akut lösemiye dönüşme riski farklılık gös-teren bir hastalıktır. MDS gelişen hastalar genellikle asemptomatiktir ve laboratuvar tetkiklerinde sitopeni dışında bozukluk görülmemektedir. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Böbrek transplantasyonu; miyelodisplastik sendromlar A AB BS S T TR RA AC CT T Immunosuppressive therapies increased incidence of de novo cancer after renal transplantation. Post-transplant lymphoproliferative disease and skin cancers are the most common malignancies in transplant patients. Myelodysplastic syndromes (MDS) are quite rare. MDS are a heterogeneous group of clonal stem cell disorders. MDS will be presented with isolated anemia and may present with severe pancytopenia. Post-transplant lymphoproliferative disease and skin cancers are the most common malignancies seen in transplant patients. This may be presented as isolated anemia as well as serious pancytopenia, even transformation to acute myeloid leukemia. Here we present a renal transplant receiving case presented by cytopenia and diagnosed as MSD. OLGU SUNUMUK Ke ey y W Wo or rd ds s: : Kidney transplantation; myelodysplastic syndromes T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J N Ne ep ph hr ro ol l 2 20 01 14 4; ;9 9( (2 2) ): :5 59 9--6 61 1Emel IŞIKTAŞ SAYILAR,

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Section: Discussionunclassified

Myelodysplastic Syndrome After Kidney Transplantation: Case Report

Sayilar¹,

Orhan²,

Ayar³

et al. 2014

Turkiye Klinikleri J Nephrol

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Azathioprine induced myelosuppression in renal transplant recipients: A study of 30 patients

Bacallao

1995

Nephrology

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The cytoskeleton is comprised of three separate filament networks: microtubules, microfilaments, and intermediate filaments. Collectively, these networks help establish and maintain the structural features of renal epithelial cells. During renal development, the cytoskeleton of the metanephric mesenchyme is extensively reorganized in order to create the cytoarchitectural elements that distinguish tubuloepithelial cells. This reorganization is coordinated with the formation of cell-cell contacts and cell-extracellular matrix interactions that are necessary to complete the developmental program. The actin cytoskeleton, microtubule network, and intermediate filament network all contribute to the development of polarity in the renal epithelial cells. The microtubule network determines the apical-basal axis of the cell. The actin cytoskeleton integrates topographic contacts between the cells and extracellular matrix. The tight junction and microvilli are subcellular structures that are associated with or comprised of actin filaments. Intermediate filament composition changes during the embryonic transition from metanephric mesenchyme to tubular epithelial cells. This review will describe the cell biology of the cytoskeletal elements in epithelial cells and the changes in cytoskeleton that accompany the formation of differentiated epithelial cells.

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Reversibles Azathioprin assoziiertes dysmyeloproliferatives Syndrom nach Nierenallotransplantation

Cited by 2 publications

References 7 publications

Myelodysplastic Syndrome After Kidney Transplantation: Case Report

Myelodysplastic Syndrome After Kidney Transplantation: Case Report

Azathioprine induced myelosuppression in renal transplant recipients: A study of 30 patients

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