Azathioprine induced myelosuppression in renal transplant recipients: A study of 30 patients

Abstract

The cytoskeleton is comprised of three separate filament networks: microtubules, microfilaments, and intermediate filaments. Collectively, these networks help establish and maintain the structural features of renal epithelial cells. During renal development, the cytoskeleton of the metanephric mesenchyme is extensively reorganized in order to create the cytoarchitectural elements that distinguish tubuloepithelial cells. This reorganization is coordinated with the formation of cell-cell contacts and cell-extracellular matrix interactions that are necessary to complete the developmental program. The actin cytoskeleton, microtubule network, and intermediate filament network all contribute to the development of polarity in the renal epithelial cells. The microtubule network determines the apical-basal axis of the cell. The actin cytoskeleton integrates topographic contacts between the cells and extracellular matrix. The tight junction and microvilli are subcellular structures that are associated with or comprised of actin filaments. Intermediate filament composition changes during the embryonic transition from metanephric mesenchyme to tubular epithelial cells. This review will describe the cell biology of the cytoskeletal elements in epithelial cells and the changes in cytoskeleton that accompany the formation of differentiated epithelial cells.

Transdifferentiation of Distal but Not Proximal Tubular Epithelial Cells from Human Kidney in Culture

“…Vimentin could perhaps be regarded as an indicator of tubuloepithelial regenerative activity [29, 30]. All these findings support the view that injury causes a loss of differentiation in epithelial cells [26, 31, 32]. …”

“…We have demonstrated the coexpression of cytokeratin and vimentin [5], first observed in immature tubuloepithelial cells [26]. The mesenchymal intermediate filament protein vimentin is normally expressed in fibroblasts and not present in differentiated epithelial cells [16].…”

miRNA let-7e targeting MMP9 is involved in adipose-derived stem cell differentiation toward epithelia

“…Stem cell differentiation may also be monitored by determining epithelial versus mesenchymal markers. During in vitro differentiation and MET, epithelial markers CK18 Griesche et al 31 and E-CAD 32 were described to be upregulated, whereas mesenchymal markers such as vimentin 33 were concomitantly downregulated. After treatment with ATRA, cells undergo significant morphological changes.…”

CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities

“…In some of the historic reports from the region, the overall mortality rate among organ transplant recipients with TB was 20% to 30%. 121,122 There are a number of issues of management of TB in the region. These include difficulties making a timely diagnosis of both active and occult TB, access to modern methods of detection and management of a potential transplant recipient with latent TB, 123…”