Reversible Thrombocytosis and Anemia Due to Miconazole Therapy

Marmion, LeRoy C.; Desser, Kenneth B.; Lilly, Ralph B.; Stevens, David A.

doi:10.1128/aac.10.3.447

Cited by 28 publications

(6 citation statements)

References 9 publications

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“…Transfusions may be required in patients who are already anaemic (Stevens 1977). Marmion et al (1976) described significant normochromic, normocytic anaemia in 6 of 6 patients receiving miconazole for coccidioidomycosis. Bone marrow aspirates performed in 3 patients demonstrated erythroid hypoplasia with adequate iron stores.…”

Section: Haematological Effectsmentioning

confidence: 99%

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

1992

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Systemic administration of antifungal agents for invasive mycoses has dramatically increased over the past 10 years in many fields of medicine. The increase has been due both to an increasing immune compromised population and to potent antibacterial agents which allow these fungi to invade tissue. It is apparent that our understanding of the use of both the old and new antifungal agents has significantly increased in the last few years. In this review, we attempt to document our extensive knowledge of the adverse effects of the polyenes, flucytosine, griseofulvin and azoles when given systemically for treatment. Interwoven in this documentation of the adverse reactions to these agents is the attempt to help clinicians potentially avoid some of these adverse effects and if they do occur, to be able to identify and successfully manage them.

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Section: Haematological Effectsmentioning

confidence: 99%

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

1992

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“…Sung and co-workers did not find effects on marrow of miconazole, but I call your readers' attention to our documentation of reversible drugrelated thrombocytosis, and anemia due to normoblastic hypoplasia. 4 The current incidence of these effects in serial observation of study patients is 30 percent and 48 percent, respectively.5 The most important side effect of miconazole therapy to be aware of is hyponatremia, which has been severe in some patients and occurs with an incidence as high as 47 percent.5…”

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confidence: 99%

Miconazole in coccidioidomycosis

Stevens¹,

Levine²,

Deresinski³

1976

The American Journal of Medicine

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121

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“…15 To improve the application of the data to the Naranjo probability scale, adaptations were made by adding thrombocytosis-specific criteria to improve the grading of case reports for causality, as seen in Table 2. For the purpose of this review, reports of suspected thrombocytosis were systematically assessed for causality (Table 3 16-45 ). The following criteria will be utilized to assess causality of a drug by case report: number of cases described by independent investigators and the Naranjo score associated with causality.…”

Section: Methodsmentioning

confidence: 99%

A Review and Assessment of Drug-Induced Thrombocytosis

Thompson

2018

Ann Pharmacother

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Objectives: The purpose of this article is to review the current literature on drug-induced thrombocytosis with the goal of critically assessing causality and providing a comprehensive review of the topic. Thrombopoietic growth factors, such as thrombopoietin-receptor agonists (romiplostim and eltrombopag) and erythropoietin are not included in our review. Data Sources: The literature search included published articles limited to the English language and humans in MEDLINE, EMBASE, and Web of Science databases. MEDLINE/PubMed (1966 to September 2018) was searched using the MeSH terms thrombocytosis/chemically-induced and thrombocytosis/etiology. EMBASE (1980 to September 2018) was searched using the EMTAGS thrombocytosis/side effect. Web of Science (1970 to September 2018) was searched using the search term thrombocytosis. References of all relevant articles were reviewed for additional citations and information. Study Selection and Data Extraction: Review articles, clinical trials, background data, case series, and case reports of drug-induced thrombocytosis were collected, and case reports were assessed for causality using a modified Naranjo nomogram. Data Synthesis: Drug-induced thrombocytosis, a form of reactive thrombocytosis cannot be easily differentiated from more common etiologies of reactive thrombocytosis. In all, 43 case reports of drug-induced thrombocytosis from a wide variety of drugs and drug classes were reviewed using a modified Naranjo probability scale that included criteria specific for thrombocytosis. Conclusions: Drug-induced thrombocytosis is a relatively rare adverse drug reaction. The strongest evidence of causality supports low-molecular-weight heparins and neonatal drug withdrawal. Weaker evidence exists for all-trans retinoic acid, antibiotics, clozapine, epinephrine, gemcitabine, and vinca alkaloids.

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Reversible Thrombocytosis and Anemia Due to Miconazole Therapy

Cited by 28 publications

References 9 publications

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

Miconazole in coccidioidomycosis

A Review and Assessment of Drug-Induced Thrombocytosis

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