Reversible splenial lesion in the corpus callosum following rapid withdrawal of carbamazepine after neurosurgical decompression for trigeminal neuralgia

Mori, Hiromu; Maeda, Masayuki; Takanashi, Jun‐ichi; Kunimatsu, Akira; Matsushima, Nobuyoshi; Suzuki, Hitomi; Saito, Nobuhito; Ohtomo, Kuni

doi:10.1016/j.jocn.2011.09.017

Cited by 16 publications

(9 citation statements)

References 17 publications

(6 reference statements)

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“…5,6 The precise etiology remains unknown. The diagnosis is based on the characteristic reversibility of both the clinical symptoms and MR imaging abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Splenial and White Matter Lesions Showing Transiently-reduced Diffusion in Mild Encephalopathy Monitored with MR Spectroscopy and Imaging

et al. 2014

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We report the time course of magnetic resonance imaging and spectroscopy of a case with lesions of the splenium and white matter with transiently reduced diffusion in clinically reversible encephalopathy. Initially normal spectroscopy showed slightly elevated choline. Signal abnormality in T 2 -weighted and fluid-attenuated inversion recovery images persisted for 90 days. Lesions of the splenium and white matter with transiently reduced diffusion in clinically reversible encephalopathy are not always reversible and may reflect heightened glial cell-membrane turnover without neuronal damage.

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“…5,6 The precise etiology remains unknown. The diagnosis is based on the characteristic reversibility of both the clinical symptoms and MR imaging abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Splenial and White Matter Lesions Showing Transiently-reduced Diffusion in Mild Encephalopathy Monitored with MR Spectroscopy and Imaging

et al. 2014

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“…[9,14,16,18,19] It was also reported that patients receiving carbamazepine for the treatment of trigeminal neuralgia without hyponatremia developed RESLES by resetting osmoreceptors and increasing renal sensitivity to play an antidiuretic effection. [20,21,22,93] Further studies are needed to confirm this hypothesis. [6] …”

Section: Discussionmentioning

confidence: 99%

Reversible splenial lesion syndrome associated with lobar pneumonia

Wu²,

Qi³

et al. 2016

Medicine

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Background:Reversible splenial lesion syndrome (RESLES) is a rare clinico-radiological disorder with unclear pathophysiology. Clinically, RESLES is defined as reversible isolated splenial lesions in the corpus callosum, which can be readily identified by magnetic resonance imaging (MRI) and usually resolve completely over a period of time. RESLES could be typically triggered by infection, antiepileptic drugs (AEDs), poisoning, etc. More factors are increasingly recognized.Methods and results:We reported herein an 18-year-old female patient with lobar pneumonia who developed mental abnormalities during hospitalization. An isolated splenial lesion in the corpus callosum was found by head MRI and the lesion disappeared 15 days later. Based on her clinical manifestations and radiological findings, she was diagnosed with lobar pneumonia associated RESLES. We further summarize the up-to-date knowledge about the etiology, possible pathogenesis, clinical manifestations, radiological features, treatment, and prognosis of RESLES.Conclusion:This report contributes to the clinical understanding of RESLES which may present with mental abnormalities after infection. The characteristic imaging of reversible isolated splenial lesions in the corpus callosum was confirmed in this report. The clinical manifestations and lesions on MRI could disappear naturally after 1 month without special treatment.

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“…AED toxicity, rapid AED withdrawal in epileptic or in nonepileptic patients using AED have been proposed to contribute to occurrence of these lesions. Some authors hypothesize that alteration in the levels of arginine‐vasopressin (AVP) created by abrupt changes in the AED causes fluid imbalance leading to edematous splenial lesions .…”

Section: Discussionmentioning

confidence: 99%

Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum

Harini

Das

Prabhu

et al. 2014

Journal of Neuroimaging

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Reversible splenial lesion in the corpus callosum following rapid withdrawal of carbamazepine after neurosurgical decompression for trigeminal neuralgia

Cited by 16 publications

References 17 publications

Splenial and White Matter Lesions Showing Transiently-reduced Diffusion in Mild Encephalopathy Monitored with MR Spectroscopy and Imaging

Splenial and White Matter Lesions Showing Transiently-reduced Diffusion in Mild Encephalopathy Monitored with MR Spectroscopy and Imaging

Reversible splenial lesion syndrome associated with lobar pneumonia

Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum

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