“…This observation has been further studied and it has been reported that incubation with ATP or ADP causes an inactivation of rabbit liver Fru-P,ase that develops slowly and can be reversed or prevented by a number of chelating agents, such as 3-P-glycerate, EDTA, pyrophosphate, citrate, oxaloacetate, phosphate Taketa et al, 1971), and oleate (Carlson et al, 1973). This observation has been confirmed by a number of other workers who have reported that swine kidney Fru-P,ase (Mendicino et al, 1966;Kratowich and Mendicino, 1970) and rabbit muscle Fru-P,ase (Fu and Kemp, 1973) are inactivated by ADP and ATP. It has been suggested that the reversal of the ADP and ATP inactivation by 3-P-glycerate may contribute to regulation of the activity of the enzyme Taketa et al, 1971).…”