Reversible and irreversible pH induced conformational changes in self-assembled weak polyelectrolyte multilayers probed using etched fiber Bragg grating sensors

Shivananju, Bannur Nanjunda; Prashanth, Gurusiddappa R.; Asokan, S.; Varma, Manoj M.

doi:10.1016/j.snb.2014.04.082

Cited by 24 publications

(10 citation statements)

References 35 publications

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“…[ 164,165 ] By functionalizing the etched‐FBG with (PAH/PAA), pH induced environment was studied to find out the charge dependence of the weak polyelectrolytes. [ 166 ] These findings show good correlation with earlier reports by Rubner et al [ 167,168 ]…”

Section: Techniques To Probe Transportsupporting

confidence: 91%

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Pahal

Boranna

Prashanth

et al. 2021

Macro Chemistry & Physics

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The matrix properties of polyelectrolyte multilayer thin films (PEM) are critical in making them a viable candidate for various biomedical applications. The location and ability of molecules to diffuse through the PEM architecture determines their encapsulation and release capabilities in a given matrix for various biomedical applications. The main aim of this review article is to provide a complete understanding of molecular transport on the surface as well as across the bulk of the PEM matrix. Different physiochemical strategies to promote or suppress the diffusivity of various molecules inside the PEM are mentioned in brief. A set of guiding principles is uncovered for getting a complete picture of loading and release of molecules across the PEM structure, which can play a key role in designing a desirable PEM assembly and have important implications for designing multicomponent, targeted and controlled drug‐delivery vehicles. Understanding the molecular diffusivity in PEM stack at the nano and micro scales will help to design superior host materials for biomedical engineering applications.

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Section: Techniques To Probe Transportsupporting

confidence: 91%

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Pahal

Boranna

Prashanth

et al. 2021

Macro Chemistry & Physics

Self Cite

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“…[ 44 ] The calibration details of the EFBG sensor have been discussed in the previous work. [ 43 ] The shift in the Bragg wavelength during the experiments was monitored using a commercial FBG interrogator system (Model SM130 from Micron Optics Inc., USA). Thickness measurements were performed using Spectroscopic ellipsometry and AFM.…”

Section: Methodsmentioning

confidence: 99%

“…We have observed a similar phenomenon in situ using the optical Etched Fiber-Bragg Grating (EFBG) technique demonstrated in our earlier works. [43,44] The adsorption of polyelectrolyte onto the EFBG sensor (as substrate) occurred rapidly. Additionally, a few pieces of the literature suggest that a shorter deposition time could also result in thicker film growth.…”

Section: Introductionmentioning

confidence: 99%

Fast‐Dip Layer‐by‐Layer Self‐Assembly of Polyelectrolytes as a Low‐Cost Biosensing Platform

Boranna

Vishwaraj

Pahal

et al. 2022

Macro Chemistry & Physics

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Polyelectrolyte multilayer (PEM) films fabricated using Layer-by-Layer (LbL) self-assembly are most versatile for numerous surface tailoring applications. Physicochemical customization of PEM at a nanometer scale is possible by choice of incorporated materials, assembly parameters, and assembly techniques. Conventional dip (CDip) (10-15 min dip time) coating dominates the PEM fabrication due to its simple, geometry-independent, and economical coating capabilities. Deposition of the PEM in CDip-LbL happens in two phases, that is, the initial adsorption phase followed by rearrangement of the complementary polyelectrolyte chains. By shortening the prolonged rearrangement phase, thicker stratified PEM films can form with a reduced dipping time (1 min), called Fast Dip (FDip). This reduction in the dipping time is studied in situ using Etched Fiber Bragg Grating-based sensors. To define the practical utility of the FDip deposited PEM, bio-molecular loading studies are performed using biotin and Bovine Serum Albumin (BSA). FDip-LbL is as effective as CDip-LbL self-assembly and also better than spin-LbL. Thus, the FDip deposition prompts a scalable LbL self-assembly process for quick fabrication of the biosensing platforms.

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“…Polyacrylic acid is a weak polyelectrolyte that replies to changes in pH and ionic strength. Polyacrylic acid block, at pH < pK a~5 , becomes less hydrophobic in aqueous solutions by reason of protonation of the carboxylate groups, which offers the polymer slightly soluble in water [27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of a Triblock Copolymer/ZnO Nanoparticles from Poly(ε-caprolactone) and Poly(Acrylic Acid) as a Potential Drug Delivery Carrier

et al. 2017

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Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and the reversible addition fragmentation chain transfer (RAFT) polymerization of the acrylic acid methods, as the drug carrier. Blends of the nanocrystalline zinc oxide nanoparticles (n-ZnO) and triblock copolymer treated from the solution have been used to make the hybrid polymer-metal oxide for the preparation of the drug loaded nanocomposite. The drug-release behavior of the nanocomposite was studied by using the Doxorubicin as a model drug. In addition to the self-assembly and pH-responsive behavior of the triblock copolymers/ZnO was studied in solution by the Fluorescence Spectroscopy, Scanning Electron Microscopy(SEM), Transmission Electron Microscopy (TEM), DLS, HNMR and FT-IR spectroscopy.

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Reversible and irreversible pH induced conformational changes in self-assembled weak polyelectrolyte multilayers probed using etched fiber Bragg grating sensors

Cited by 24 publications

References 35 publications

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Fast‐Dip Layer‐by‐Layer Self‐Assembly of Polyelectrolytes as a Low‐Cost Biosensing Platform

Synthesis and Evaluation of a Triblock Copolymer/ZnO Nanoparticles from Poly(ε-caprolactone) and Poly(Acrylic Acid) as a Potential Drug Delivery Carrier

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