Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency?

Ishibashi, Sachiko; Yokota, Takanori; Shiojiri, Toshiaki; Matunaga, Tadaharu; Tanaka, Hiroaki; Nishina, Kahoru; Hirota, H; Inaba, Akira; Yamada, Miki; Kanda, Takashi; Mizusawa, Hidehiro

doi:10.1136/jnnp.74.5.674

Cited by 37 publications

(37 citation statements)

References 14 publications

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“…One study has shown that thiamine supplementation does not significantly increase brain thiamine compound levels [66]. Yet there have been reports that thiamine administration reduces and even reverses motor-sensory polyneuropathy in Wenicke-Korsakoff's syndrome and post-gastrectomy [98,99]. This highlights that brain thiamine homeostasis by thiamine specific transporters, enzymatic phosphorylation and de-phosphorylation is still not fully understood.…”

Section: Neurodegenerationmentioning

confidence: 98%

Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS). This review aims to explore analytical methodologies of thiamine compound quantification and highlight similarities, variances and limitations of current techniques and how they may be relevant to patients. Content: An electronic search of Medline, PubMed and Embase databases for original articles published in peerreviewed journals was conducted. MethodsNow was used to search for published analytical methods of thiamine compounds. Keywords for all databases included "thiamine and its phosphate esters", "thiamine methodology" and terms related to critical illness. Enquiries were also made to six external quality assurance (EQA) programme organisations for the inclusion of thiamine measurement.

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Section: Neurodegenerationmentioning

confidence: 98%

Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Acute axonal polyneuropathy and Wernicke-Korsakoff encephalopathy developed simultaneously in three patients. Their symptoms of neuropathy lessened within two weeks after an intravenous thiamine infusion [151]. These findings suggest that impaired physiological nerve conduction due to thiamine deficiency.…”

Section: Other Rolementioning

confidence: 60%

The Role of Thiamine in Autism

Lương¹

2013

AJPN

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Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed.

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“…Sural nerve biopsies in two patients revealed mild axonal degeneration with scattere d myelin ovoid formation. The authors proposed thre e d i ff e rent mechanisms for the axonal dysfunction: distal conduction block due to demyelination, distal a x onal regeneration and physiological conduction failure on the axolemma 16 .…”

Section: Discussionmentioning

confidence: 99%

Acute axonal polyneuropathy with predominant proximal involvement: an uncommon neurological complication of bariatric surgery

Machado

Valério

Morgulis

et al. 2006

Arq. Neuro-Psiquiatr.

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Bariatric surgery is frequently indicated in the treatment of morbid obesity. Previously unreported complications have been associated to this surgery; among them, neurological complications have gained attention. We report the case of a 25-year-old man submitted to gastric surgery for treatment of morbid obesity who developed, two months after surgery, acute proximal weakness in lower limbs. The electroneuromyography revealed axonal peripheral polyneuropathy with predominant proximal involvement. After treatment with immunoglobulin and vitamin supplementation, rapid clinical and neurophysiologic recovery was observed. We describe the clinical and electroneuromyographic features of this case, stressing the difficulty of initial diagnosis, particularly in the differential diagnosis with Guillain-Barré syndrome. We discuss the importance of nutritional follow-up and the eventual indication of routine vitamin supplementation in these patients.

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Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency?

Cited by 37 publications

References 14 publications

Vitamin B1 in critically ill patients: needs and challenges

Vitamin B1 in critically ill patients: needs and challenges

The Role of Thiamine in Autism

Acute axonal polyneuropathy with predominant proximal involvement: an uncommon neurological complication of bariatric surgery

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