Reversed-phase high-performance thin-layer chromatographic method for the simultaneous determination of glycyrrhizin and glabridin biomarkers in <i>Glycyrrhiza glabra</i> roots, rhizomes and herbal formulations

Alam, Prawez; Kamal, YT; Alqarni, Mohammed H.; Zaatout, Hala H.; Abdel‐Kader, Maged S.

doi:10.1556/1006.2018.31.2.7

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Licorice or licorice extract can be added to beer, for emulsifying and foaming purposes and for regulating the color and concentration of beer . Added to bread and other baked foods, it can play a role in loosening, increasing the elasticity, and improving the mouthfeel. , Licorice flavonoids are added to food and can play a role in preventing mildew infestation . In addition, licorice is also used in tobacco, toothpaste, lotion, cosmetics, and other industries. , …”

Section: Introductionmentioning

confidence: 99%

“…Added to bread and other baked foods, it can play a role in loosening, increasing the elasticity, and improving the mouthfeel. , Licorice flavonoids are added to food and can play a role in preventing mildew infestation . In addition, licorice is also used in tobacco, toothpaste, lotion, cosmetics, and other industries. , …”

Section: Introductionmentioning

confidence: 99%

“…14 In addition, licorice is also used in tobacco, toothpaste, lotion, cosmetics, and other industries. 20,21 The active components of licorice mainly include triterpenoids, polysaccharides, flavonoids, and so on. 15,22 Licorice roughly contains a hundred and one biological activities, which include anti-cancer, antioxidant, and anti-inflammatory activities.…”

Section: ■ Introductionmentioning

confidence: 99%

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Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study

Luo

et al. 2021

J. Agric. Food Chem.

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Type 2 diabetes mellitus (T2DM) is a type of metabolic illness based on relatively insufficient insulin secretion and insulin resistance (IR) as pathophysiological bases. Currently, it is the main type of diabetes. Hypoglycemic and hypolipidemic effects of licochalcone A (LicA) on high-fat diet and streptozocin-caused T2DM were studied. LicA can remarkably decline the IR index and blood glucose and serum lipid levels. Also, the treatment of LicA can improve the "three more and one less" phenomenon in T2DM mice, such as excessive drinking, eating, urine, and weight loss. In addition, LicA can improve oral glucose tolerance, pancreatic injury, and liver enlargement in T2DM mice. Network pharmacology analysis demonstrated that the observed pharmacological effects were mediated by regulating the insulin signal transduction pathway. Therefore, the PI3K/Akt-signaling pathway was selected for verification; it was demonstrated that LicA could improve the insulin-signaling pathway, protect islet cells, improve IR, reduce blood glucose levels, and alleviate lipid metabolism disorder. Its mechanism of influence may be closely related to LicA up-regulating the liver and pancreas IRS-2/PI3K/AKT-signaling pathway. Among them, the high-dose group of LicA had the best effect, which provided an idea for the use of LicA as a nutritional agent in the cure of T2DM.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study

Luo

et al. 2021

J. Agric. Food Chem.

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“…Nevertheless, with the development of high-performance TLC (HPTLC) and the introduction of modern instrument that can provide standardized conditions, the performance of TLC has been significantly improved. Up to date, TLC and HPTLC has been successfully applied to the quantitative analysis of active ingredients in a series of herbal drugs including Astragali Radix [ 39 ], Magnoliae Officinalis Cortex [ 40 ] and Glycyrrhizae Radix et Rhizoma [ 41 ], etc. In addition, TLC-bioautography that combines TLC separation with bioassay provides a supreme method for the screening of bioactive compounds from herbal drugs directly.…”

Section: Advanced Analytical Techniques For Quality Standard Of Tcmmentioning

confidence: 99%

Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances

et al. 2020

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Traditional Chinese medicine (TCM) are becoming more and more popular all over the world. However, quality issues of TCM may lead to medical incidents in practice and therefore quality control is essential to TCM. In this review, the state of TCM in European Pharmacopoeia are compared with that in Chinese Pharmacopoeia, and herbal drugs that are not considered as TCM and not elaborated by TCM working party at European Directorate for the Quality of Medicines & Health Care (EDQM) but present in both European Pharmacopoeia and Chinese Pharmacopoeias are also discussed. Different aspects in quality control of TCM including origins, identification, tests and assays, as well as sample preparation, marker selection and TCM processing are covered to address the importance of establishing comprehensive quality standard of TCM. Furthermore, advanced analytical techniques for quality control and standard establishment of TCM are also reviewed. Electronic supplementary material The online version of this article (10.1186/s13020-020-00357-3) contains supplementary material, which is available to authorized users.

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Simultaneous identification of rutin, chlorogenic acid and gallic acid in Moringa oleifera by densitometric high-performance thin-layer chromatography method

Alam

Sharafeldin

Alqarni

2020

JPC-J Planar Chromat

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Reversed-phase high-performance thin-layer chromatographic method for the simultaneous determination of glycyrrhizin and glabridin biomarkers in Glycyrrhiza glabra roots, rhizomes and herbal formulations

Cited by 4 publications

References 17 publications

Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study

Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study

Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances

Simultaneous identification of rutin, chlorogenic acid and gallic acid in Moringa oleifera by densitometric high-performance thin-layer chromatography method

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