Reversed end‐diastolic flow in the umbilical artery at 10–14 weeks of gestation is associated with absent pulmonary valve syndrome

Berg, Christoph; Thomsen, Y; Geipel, A.; Germer, U.; Gembruch, Ulrich

doi:10.1002/uog.4098

Cited by 31 publications

(26 citation statements)

References 30 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This in particular applies to Fallot type APVS. 7 Prognosis of APVS remains poor. Apart from cardiac complications most of the infants develop complications secondary to respiratory distress.…”

Section: Discussionmentioning

confidence: 99%

Absent pulmonary valve syndrome – Antenatal diagnosis

Grewal¹,

Chamoli²,

Saxena

2014

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Absent pulmonary valve syndrome – Antenatal diagnosis

Grewal¹,

Chamoli²,

Saxena

2014

Medical Journal Armed Forces India

View full text Add to dashboard Cite

“…It is characterized by the absence or extremely vestigial development of the pulmonary valve leaflets in association with varying degrees of hypoplasia of the pulmonary annulus [1] . The absence of the ductus arteriosus is frequently described in association with TOF and APVS in the second trimester whereas a patent ductus arteriosus is predominant in early gestation and is associated with massive volume overload of both ventricles resulting in hydrops and early fetal death [2] . A right aortic arch is present in up to 30% of patients with TOF; the mirror image branching pattern of the brachiocephalic vessels is usually present instead of an aberrant left subclavian artery observed in our case [3] that may occur in up to 25% of the cases with TOF and right aortic arch.…”

Section: Discussionmentioning

confidence: 99%

Ebstein’s Anomaly of the Tricuspid Valve in Association with Tetralogy of Fallot and Absent Pulmonary Valve Syndrome

Abramian¹,

Gembruch²,

Geipel³

et al. 2011

Fetal Diagn Ther

Self Cite

View full text Add to dashboard Cite

Ebstein’s anomaly and absent pulmonary valve syndrome belong to the rarest congenital heart defects. Their association has never been reported so far. We present the unusual case of a fetus at 23 weeks of gestation with Ebstein’s anomaly, tetralogy of Fallot, absent pulmonary valve and agenesis of the arterial duct. The main diagnostic features were apical displacement of the septal leaflet of the tricuspid valve with an offset from the mitral valve of 8 mm, a pronounced atrialization of the right ventricle, a large malalignment ventricular septal defect with overriding aorta in combination with absence of the pulmonary valve leaflets, to and fro flow pattern over the stenotic pulmonary valve annulus, turbulent flow in the pulmonary trunk, massive dilatation of the pulmonary trunk plus the pulmonary arteries and a right aortic arch with retroesophageal course of an aberrant left subclavian artery. The arterial duct and the thymus were absent. The remaining fetal anatomy was unremarkable. Amniocentesis revealed a normal male karyotype; 22q11 microdeletion was ruled out. After being counseled on the unfavorable prognosis, the parents opted for termination of pregnancy. The prenatal cardiac findings were confirmed at autopsy; however, a severely hypoplastic thymus was found instead of the suspected aplasia.

show abstract

“…In particular in the case of an open arterial duct, this special hemodynamic situation causes a significant volume load on both ventricles which typically results in the death of the fetus in the first or early second trimester. Atresia of the arterial duct is usually present in cases diagnosed later in pregnacy, as it restricts the volume load to the right ventricle and is thus tolerable for the fetus [23]. However, even in this situation the prognosis is very unfavorable as the remaining volume load often leads to hydrops and death.…”

Section: Tetralogy Of Fallotmentioning

confidence: 99%