Reverse vesicle formation from the yeast glycolipid biosurfactant mannosylerythritol lipid-D

Fukuoka, Tokuma; Yanagihara, Takashi; Ito, Seya; Imura, Tomohiro; Morita, Tomotake; Sakai, Hideki; Abe, Masahiko; Kitamoto, Daï

doi:10.5650/jos.61.285

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…In B16 cells exposed to 5 mmol/L MELs for 2 days, the protein kinase PKC was enhanced. Then, B16 cells under 10 mmol/L MELs entered the G1 phase and began apoptosis within 24 h [ 25 ].…”

Section: Application Of Biosurfactants In Medical Sciencesmentioning

confidence: 99%

Application of Biosurfactants in Medical Sciences

Wang,

An,

Cao

et al. 2024

Molecules

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Biosurfactants derived from microorganisms have attracted widespread attention in scientific research due to their unique surface activity, low toxicity, biodegradability, antibacterial properties, and stability under extreme conditions. Biosurfactants are widely used in many fields, such as medicine, agriculture, and environmental protection. Therefore, this review aims to comprehensively review and analyze the various applications of biosurfactants in the medical field. The central roles of biosurfactants in crucial medical areas are explored, like drug delivery, induction of tumor cell differentiation or death, treating bacterial and viral effects, healing wounds, and immune regulation. Moreover, a new outlook is introduced on optimizing the capabilities of biosurfactants through modification and gene recombination for better use in medicine. The current research challenges and future research directions are described, aiming to provide valuable insights for continuous study of biosurfactants in medicine.

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“…In B16 cells exposed to 5 mmol/L MELs for 2 days, the protein kinase PKC was enhanced. Then, B16 cells under 10 mmol/L MELs entered the G1 phase and began apoptosis within 24 h [ 25 ].…”

Section: Application Of Biosurfactants In Medical Sciencesmentioning

confidence: 99%

Application of Biosurfactants in Medical Sciences

Wang,

An,

Cao

et al. 2024

Molecules

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“…MEL-A and MEL-D can be used to prepare stable W/O microemulsions without the addition of a co-surfactant or salt. 28,29 Another study investigated the aqueous-phase behavior, capability of self-assembling and vesicle-forming activity of MEL-B. 30 Overall, it can be concluded that MEL S has shown distinct emulsifying activity to form stable W/O microemulsions in the absence of co-surfactants or salts.…”

Section: Glycolipid Biosurfactants As Ingredients For Microemulsion Smentioning

confidence: 99%

<p>Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review</p>

Ohadi¹,

Shahravan²,

Dehghannoudeh³

et al. 2020

DDDT

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Background: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules because of their lower toxicity and safe characteristics when compared to synthetic surfactants. Glycolipid and lipopeptide are the most common biosurfactants that were tested for MDDS. The main goal of the present systematic review was to estimate the available evidence on the role of biosurfactant in the development of MDDS. Search Strategy: Literature searches involved the main scientific databases and were focused on the period from 2005 until 2017. The Search filter composed of two items: "Biosurfactant" and/or "Microemulsion." Inclusion Criteria: Twenty-four studies evaluating the use of biosurfactant in MDDS were eligible for inclusion. Among these 14 were related to the use of glycolipid biosurfactants in the MDDS formulations, while four reported using lipopeptide biosurfactants and six other related review articles. Results: According to the output study parameters, biosurfactants acted as active stabilizers, hydrophilic or hydrophobic linkers and safety carriers in MDDS, and among them glycolipid biosurfactants had the most application in MDDS formulations. Conclusion: Synthetic surfactants could be replaced by biosurfactants as an effective biosource for MDDS due to their excellent self-assembling and emulsifying activity properties.

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“…8 Only mannosylerythritole lipids (MEL) have been studied at concentrations above 20 wt% by the group of Kitamoto et al, who mainly observed uni-and multilamellar vesicles below about 60 wt% and an Lα phase above 60 wt% for MEL-A, B, C, and D, except for MEL-A, which forms cubic (V2) and coacervate (L3) phases below 65 wt% and 55 wt%, respectively. [12][13][14][15][16][17] There are several reasons why there is only a limited amount of work that addresses the lyotropic behavior of microbial amphiphiles. First of all, such studies require important amounts of material, which is hardly possible for most microbial fermentations.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the self-assembly properties of biological amphiphiles obtained by microbial fermentation have been studied only since the late 1980s, and they generally only pertain to the study of diluted systems . Only mannosylerythritole lipids (MEL) have been studied at concentrations above 20 wt % by the group of Kitamoto et al, who mainly observed uni- and multilamellar vesicles below about 60 wt % and an L α phase above 60 wt % for MEL-A, MEL-B, MEL-C, and MEL-D, except for MEL-A, which forms cubic (V2) and coacervate (L3) phases below 65 and 55 wt %, respectively. − …”

Section: Introductionmentioning

confidence: 99%