<p>Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review</p>

Abstract

Background: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules because of their lower toxicity and safe characteristics when compared to synthetic surfactants. Glycolipid and lipopeptide are the most common biosurfactants that were tested for MDDS. The main goal of the present systematic review was to estimate the available evidence on the role of biosurfactant in the development of MDDS. Search Strategy: Literature searches involved the main scientific databases and were focused on the period from 2005 until 2017. The Search filter composed of two items: "Biosurfactant" and/or "Microemulsion." Inclusion Criteria: Twenty-four studies evaluating the use of biosurfactant in MDDS were eligible for inclusion. Among these 14 were related to the use of glycolipid biosurfactants in the MDDS formulations, while four reported using lipopeptide biosurfactants and six other related review articles. Results: According to the output study parameters, biosurfactants acted as active stabilizers, hydrophilic or hydrophobic linkers and safety carriers in MDDS, and among them glycolipid biosurfactants had the most application in MDDS formulations. Conclusion: Synthetic surfactants could be replaced by biosurfactants as an effective biosource for MDDS due to their excellent self-assembling and emulsifying activity properties.

Effect of hydrophobically modified PEO polymers (PEO-dodecyl) on oil/water microemulsion properties: in vitro and in silico investigations

“…28,29 Compared to a conventional emulsion, a microemulsion is a better vector for the active agents because it consists of nanodroplets that allow better penetration of these active agents. [30][31][32] It also has the advantage of being prepared cold, [33][34][35] which on the one hand reduces energy consumption during its preparation, and on the other hand, it uses heat-sensitive active ingredients. Thus, in comparison with micellar solutions, microemulsions can solubilize a greater quantity of active agents due to their greater stability partly due to the presence of a greater quantity of surfactant, which can, on the other hand, constitute an obstacle to their use for reasons of cost and/or toxicity.…”

The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range

“…Very recently, it was also suggested that surfactin can effectively demulsify waste crude oil (Yang et al, 2020 ). Their emulsifying property also confers them a potential of application in the food and cosmetics area for the product formulation (Mnif et al, 2013 ; Varvaresou and Iakovou, 2015 ; Zouari et al, 2016 ) as well as in the pharmaceutical area for the formulation of stable microemulsion drug delivery systems (Ohadi et al, 2020 ).…”

Surfactants: physicochemical interactions with biological macromolecules

“…In the biomedical industry, protein–surfactant systems are used for the production of hydrogels (Afinjuomo et al 2019 ; Castelli et al 2008 ). The hydrogels form the base of fibrous proteins such as fibroin, which are used for tissue regeneration and drug delivery (Park et al 2014 ; Dubey et al 2018 ; Ohadi et al 2020 ).…”