“…South America has a great transborder groundwater reservoir named the Guarani Aquifer System (GAS), which is located in Brazil, Argentina, Paraguay, and Uruguay. The area of the GAS is 1,194,000 km², with Southern Brazil comprising the largest area [8]. However, in confined regions, the water is brackish and has a fluoride concentration exceeding 1.5 mg/L, thus, is unfit for human consumption [8,9].…”