Reverse Multidrug Resistance in Human HepG2/ADR by Anti-miR-21 Combined with Hyperthermia Mediated by Functionalized Gold Nanocages

Wang, Weiping; Huang, Shengnan; Yuan, Jinxiu; Xu, Xin; Li, Huili; Lv, Zhanwei; Yu, Wei; Duan, Shaofeng; Hu, Yurong

doi:10.1021/acs.molpharmaceut.8b00046

Cited by 19 publications

(16 citation statements)

References 39 publications

(60 reference statements)

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“…To evaluate the potential application of the constructed MIP nanoparticles in DDS, the cytotoxicity tests of MIP and N-MIL on HepG2 cells and HL-7702 cells [ 41 , 42 , 43 , 44 , 45 , 46 ] were detected by MTT method ( Figure 8 ). The cell viability showed that the inhibition rate increased with time increasing.…”

Section: Resultsmentioning

confidence: 99%

Molecularly Imprinting Polymers (MIP) Based on Nitrogen Doped Carbon Dots and MIL-101(Fe) for Doxorubicin Hydrochloride Delivery

et al. 2020

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MIL-based molecularly imprinted polymer (MIP) nanocomposites were successfully synthesized through a simple and versatile stirring auxiliary encapsulation method. MIP as a carrier has been applied to the highly efficient selective recognition and sustained release of doxorubicin hydrochloride (DOX). The adsorption mechanism and release behavior of MIP@DOX in vitro were also discussed. Adsorption studies showed that MIP using DOX as template had specific selectivity to DOX, and its optimal drug loading efficiency reached 97.99%. The adsorption isotherm accorded with Freundlich models. The cumulative release curve showed that at the conditions of pH 5.5 and 7.4, the nanomaterials have a slow-release effect on the release of DOX. In addition, the cytotoxicity and bioactivity of MIP nanoparticles on HepG2 and HL-7702 cell lines measured by MTT assay also proved their low toxicity and biological activity. The cell activity of HepG2 and HL-7702 incubated with MIP for 24 h was 69.9% and 76.07%, respectively. These results collectively illustrated that the MIP nano-materials synthesized in this study can be efficiently employed to the drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Molecularly Imprinting Polymers (MIP) Based on Nitrogen Doped Carbon Dots and MIL-101(Fe) for Doxorubicin Hydrochloride Delivery

et al. 2020

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“…Therefore, a novel nanoparticle system was synthesized, HA/anti-miR-21/PPAuNCs (HA-conjugated, anti-miR-21-loaded, PEI-modified PEGylated AuNCs). In addition to enhancing the sensitivity of HepG2/ADR cell line to chemotherapy, AuNCs can also play the role of PTT by mild near-infrared irradiation ( 53 ).…”

Section: Pttmentioning

confidence: 99%

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

2021

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Hepatocellular carcinoma (HCC) is the most common primary liver tumor. It is ranked the sixth most common neoplasm and the third most common cause of cancer mortality. At present, the most common treatment for HCC is surgery, but the 5-year recurrence rates are still high. Patients with early stage HCC with few nodules can be treated with resection or radiofrequency ablation (RFA); while for multinodular HCC, transarterial chemoembolization (TACE) has been the first-line treatment. In recent years, based on medical engineering cooperation, nanotechnology has been increasingly applied to the treatment of cancer. Photodynamic therapy and photothermal therapy are effective for cancer. This paper summarizes the latest progress of photodynamic therapy and photothermal therapy for HCC, with the aim of providing new ideas for the treatment of HCC.

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“…This strategy significantly inhibited the overexpression of p‐glycoprotein (p‐gp) in the resistant cells and increased their sensitivity to DOX. [ 122 ]…”

Section: Vectors For Hcc Gene Therapymentioning

confidence: 99%

Gene Therapy for Hepatocellular Carcinoma: Highlighting the Journey from Theory to Clinical Applications

Younis

Khalil

Harashima

2020

Advanced Therapeutics

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Treatment for hepatocellular carcinoma (HCC) is currently limited to early stages where surgical intervention is applicable. Meanwhile, the response for most chemotherapies is still low, leaving patients in advanced stages without an effective therapeutic approach. Other therapeutic strategies based on immunotherapies or radiotherapy have a narrow spectrum with multiple limitations. These collective drawbacks necessitate the development of alternative strategies. Gene therapy has achieved a breakthrough in the treatment of several diseases, especially tumors. In the current review, a discussion is provided on the various strategies that have been developed for HCC gene therapy, the functional and genetic materials used, and their diverse delivery systems, with a special focus on novel targeting strategies based on biomaterials, peptide libraries, and aptamers. In addition, animal models that have been used in preclinical evaluation of HCC gene therapies are highlighted and compared. Lastly, ongoing clinical trials and future perspectives for these strategies are discussed.

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Reverse Multidrug Resistance in Human HepG2/ADR by Anti-miR-21 Combined with Hyperthermia Mediated by Functionalized Gold Nanocages

Cited by 19 publications

References 39 publications

Molecularly Imprinting Polymers (MIP) Based on Nitrogen Doped Carbon Dots and MIL-101(Fe) for Doxorubicin Hydrochloride Delivery

Molecularly Imprinting Polymers (MIP) Based on Nitrogen Doped Carbon Dots and MIL-101(Fe) for Doxorubicin Hydrochloride Delivery

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

Gene Therapy for Hepatocellular Carcinoma: Highlighting the Journey from Theory to Clinical Applications

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