Reversal of the Inhibitory Action of Adrenaline and Histamine on Rat Uterus

Jensen, Kjell Briseid; Vennerød, Anne Marie

doi:10.1111/j.1600-0773.1961.tb01671.x

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…Some investigators suggested that histamine-induced uterine relaxation is associated with activation of the histamine H 2 -receptors [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus

Hassan¹,

Eldin²,

Ahmed³

et al. 2013

Health

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Background: Medicinal plants contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments. Objectives and Methods: This study aimed to investigate the effects of the methanolic extract of Pausinystalia yohimbe bark (5 mg/ml) on isolated rabbit aortic strip and rat uterus. Results: methanolic extract of P. yohimbe bark (5 mg/ml) produced relaxation of the phenylephrine precontracted-rabbit aortic strip. This relaxation may be resulted through nitric oxide (NO), since the pretreatment of the isolated rabbit aortic strip with methylene blue inhibited the NO-mediated relaxation. Moreover, the extract exhibited relaxation of rat uterine muscles, which appeared to be not mediated by activation of β 2 -adrenoceptors and/or H 2 receptors, since the relaxant effect continued even after the pretreatment of the tissue with propranolol and ranitidine respectively. Conclusion: The obtained results revealed that methanolic extract of P. yohimbe bark caused relaxation of both isolated rat uterus and rabbit aortic strip through facilitating the role of endogenous compounds such as NO.

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“…Some investigators suggested that histamine-induced uterine relaxation is associated with activation of the histamine H 2 -receptors [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus

Hassan¹,

Eldin²,

Ahmed³

et al. 2013

Health

View full text Add to dashboard Cite

show abstract

Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Marshall¹

1970

Rev. Physiol. Biochem. Pharmacol.

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Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Marshall

Reviews of Physiology, Biochemistry and Pharmacology

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Reversal of the Inhibitory Action of Adrenaline and Histamine on Rat Uterus

Cited by 11 publications

References 8 publications

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus

Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

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Reversal of the Inhibitory Action of Adrenaline and Histamine on Rat Uterus

Cited by 11 publications

References 8 publications

Effects of methanolic extract of yohimbe bark (&lt;i&gt;Pausinystalia yohimbe&lt;/i&gt;) on isolated rabbit aortic strip and rat uterus

Effects of methanolic extract of yohimbe bark (&lt;i&gt;Pausinystalia yohimbe&lt;/i&gt;) on isolated rabbit aortic strip and rat uterus

Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Contact Info

Product

Resources

About

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus

Effects of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on isolated rabbit aortic strip and rat uterus