Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Marshall, J. F.

doi:10.1007/bf02628455

Cited by 86 publications

(55 citation statements)

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“…The mammalian uterus is innervated by postganglionic noradrenaline-containing (NA-C) sympathetic nerves which innervate blood vessels and myometrial smooth muscle (Marshall, 1970 ;Owman & Stjernquist, 1988 ;Papka & Traurig, 1992). The sympathetic nerve supply to the uterus is described as Correspondence to Dr M. M. Brauer, Divisio!…”

Section: mentioning

confidence: 99%

“…: (0598-2) 4871623 (ext. 116) ; fax : (0598-2) 487-5548 ; e-mail : brauer!iibce.edu.uy composed of ' long ' postganglionic fibres, whose cell bodies are in the inferior mesenteric and paravertebral sympathetic chain ganglia, and ' short ' postganglionic fibres originating in the paracervical ganglia, located in the mesentery of the uterovaginal junction (Marshall, 1970 ;Kanerva et al 1972 ;Owman & Stjernquist, 1988).…”

Section: mentioning

confidence: 99%

“…For more than 3 decades sex-hormone and pregnancyinduced plasticity in uterine sympathetic nerves has been interpreted as a direct and selective effect of ovarian\placental hormones on the system of short sympathetic neurons innervating the female genital organs (Marshall, 1970(Marshall, , 1981Thorbert, 1978 ;Owman, 1981 ;Owman & Stjernquist, 1988). More recently, the possibility that the uterus could regulate its state of innervation through hormonal-induced variations in the local production of neurotrophic factors has been suggested (Owman & Stjernquist, 1988 ;Corbacho et al 1997 ;Haase et al 1997 ;Zoubina et al 1998).…”

Section: mentioning

confidence: 99%

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Effects of chronic oestrogen treatment are not selective for uterine noradrenaline‐containing sympathetic nerves: a transplantation study

et al. 2000

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Previous studies have shown that chronic administration of oestrogen during postnatal rat development dramatically reduces the total content of noradrenaline in the uterine horn, abolishes myometrial noradrenergic innervation and reduces noradrenaline-fluorescence intensity of intrauterine perivascular nerve fibres. In the present study we analysed if this response is due to a direct and selective effect of oestrogen on the uterine noradrenaline-containing sympathetic nerves, using the in oculo transplantation method. Small pieces of myometrium from prepubertal rats were transplanted into the anterior eye chamber of adult ovariectomised host rats. The effect of systemic chronic oestrogen treatment on the reinnervation of the transplants by noradrenaline-containing sympathetic fibres from the superior cervical ganglion was analysed on cryostat tissue sections processed by the glyoxylic acid technique. In addition, the innervation of the host iris was assessed histochemically and biochemically. The histology of the transplants and irises was examined in toluidine blue-stained semithin sections. These studies showed that after 5 wk in oculo, the overall size of the oestrogen-treated transplants was substantially larger than controls, and histology showed that this change was related to an increase in the size and number of smooth muscle cells within the transplant. Chronic oestrogen treatment did not provoke trophic changes in the irideal muscle. Histochemistry showed that control transplants had a rich noradrenergic innervation, associated with both myometrium and blood vessels. Conversely, in oestrogen-treated transplants only occasional fibres were recognised, showing a reduced NA fluorescence intensity. No changes in the pattern and density of innervation or in the total content of noradrenaline of the host irises were detected after chronic exposure to oestrogen. We interpreted these results to indicate that the effects of oestrogen on uterine noradrenaline-containing sympathetic nerves are neither selective or direct, but result from an interaction between sympathetic nerve fibres with the oestradiol-primed uterine tissue. A potential effect of oestrogen on the neurotrophic capacity of the uterus is discussed.

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confidence: 99%

Section: mentioning

confidence: 99%

Section: mentioning

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Effects of chronic oestrogen treatment are not selective for uterine noradrenaline‐containing sympathetic nerves: a transplantation study

et al. 2000

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“…Agonists at P-adrenoceptors are potent inhibitors of uterine contractions both in vitro and in vivo with a rapid onset of action (Marshall, 1970;Hollingsworth & Schnieden, 1973;Liggins & Vaughan, 1973). This direct action is the pharmacological basis for the use of compounds such as ritodrine and salbutamol in the treatment of preterm labour.…”

Section: Introductionmentioning

confidence: 99%

The effects of long‐term infusion of salbutamol, diltiazem and nifedipine on uterine contractions in the ovariectomized, post‐partum rat

Abel

Hollingsworth

1986

British J Pharmacology

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1 The sensitivity of the uterus to the inhibition ofcontractions by salbutamol, diltiazem or nifedipine was assessed in the ovariectomized, post-partum rat by dose-response curves following bolus intravenous (i.v.) administration. These tests were performed before (day 1), immediately after a 20 h i.v. infusion of salbutamol, diltiazem, nifedipine or appropriate control infusate (day 2) and after a further 20 h infusion of saline (day 3). In a further group of animals sensitivity to nifedipine was assessed before and after a 20 h infusion of salbutamol. Uterine contractions were monitored throughout infusions.2 Infusion of salbutamol (2;tg kg-'min-') produced an initial marked inhibition of uterine contractions, an effect which was not maintained despite continued infusion. Contractions reappeared after 2 h of infusion and reached pre-infusion levels by 5 h. The dose-response curve to salbutamol on day 2 was shifted more than 100 fold to the right compared with that on day 1. Sensitivity of the uterus on day 3 did not differ from that on day 1. 3 Nifedipine (25 tg kg-min ')produced sustained inhibition of uterine contractions throughout the 20 h of infusion. Sensitivity of the uterus to nifedipine could not, therefore, be tested on day 2; sensitivity on day 3 did not differ from that on day 1. In addition, there was no change in sensitivity of the uterus to nifedipine after a 20 h infusion of salbutamol. 4 Diltiazem (200 Ig kg-' min-') produced a marked initial inhibition of uterine contractions, with a partial return of contractions during continued infusion in 7 out of 12 animals so that mean integral values reached 40% of those pre-infusion. The dose-response curve to diltiazem on day 2 showed a 25 fold shift to the right compared with that on day 1 in 4 out of 12 animals where the test could be performed. Sensitivity of the uterus on day 3 did not differ from that on day 1. 5 These findings suggest that marked but reversible tolerance to the inhibitory actions of salbutamol on uterine contractions occurs during long-term infusion. There was no evidence of tolerance to the uterine actions of nifedipine, but there was evidence of tolerance to diltiazem in some animals.

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“…Comme il existe des variations de la sensibilité de l'oviducte de la brebis aux stimulations adrénergiques selon la région examinée (Ruckebusch et Pichot, 1975) (Marshall, 1970). Chez la Brebis, Rexroad (1981) …”

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Etude des réponses motrices de l'utérus aux catécholamines chez la brebis sous différentes imprégnations stéroïdiennes. Mise en évidence du rôle des catécholamines endogènes

PRUD'HOMME¹,

COUTHERUT²,

JAMAIN³

1984

Reprod. Nutr. Dévelop.

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Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

Cited by 86 publications

References 123 publications

Effects of chronic oestrogen treatment are not selective for uterine noradrenaline‐containing sympathetic nerves: a transplantation study

Effects of chronic oestrogen treatment are not selective for uterine noradrenaline‐containing sympathetic nerves: a transplantation study

The effects of long‐term infusion of salbutamol, diltiazem and nifedipine on uterine contractions in the ovariectomized, post‐partum rat

Etude des réponses motrices de l'utérus aux catécholamines chez la brebis sous différentes imprégnations stéroïdiennes. Mise en évidence du rôle des catécholamines endogènes

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