Abstract:Two‐photon (TP) imaging with a donor‐acceptor (D−A) type fluorophore is an emerging tool for bioimaging and sensing. However, current TP probes suffer from serious solvatochromic quenching in aqueous solution due to their strong intramolecular charge transfer (ICT) in excited states. In this work, based on solvatochromism reversal, we report a novel strategy to develop TP probes for bioimaging. Specifically, compared with the normal two‐photon probes that showed a fluorescence off with ICT suppressed, the nove… Show more
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