Reversal of Soft-Tissue Local Anesthesia With Phentolamine Mesylate in Pediatric Patients

Tavares, Mary; Goodson, J. Max; Studen-Pavlovich, Deborah; Yagiela, John A.; Navalta, Laura; Rogy, Siegfried; Rutherford, Bruce; Gordon, Sharon M.; Papas, Athena

doi:10.14219/jada.archive.2008.0312

Cited by 53 publications

(42 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phentolamine is a nonselective, alpha-adrenergic blocking agent that has been available in the United States since 1952 for the clinical reversal of accidental extravasation of catecholamines during intravenous administration and for the diagnosis of pheochromocytoma (2,3). The primary action of phentolamine is vasodilation (2)(3)(4).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Fowler

Nusstein

Drum

et al. 2011

Journal of Endodontics

View full text Add to dashboard Cite

mentioning

confidence: 99%

“…A number of well-controlled studies have shown that phentolamine statistically reduces the time of soft-tissue numbness when compared with a sham treatment (2)(3)(4)(5). Side effects have been reported as minimal and similar to a sham treatment (2)(3)(4)(5).…”

mentioning

confidence: 99%

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Fowler

Nusstein

Drum

et al. 2011

Journal of Endodontics

View full text Add to dashboard Cite

“…Similar results in additional pediatric subjects (ages 6 to 11 years of age) have been recently reported. 35 In all OraVerse clinical trials, there were no serious adverse events reported. The most common adverse reaction was transient injection site pain.…”

Section: Reversal Of Dental Anesthesiamentioning

confidence: 92%

Local Anesthesia and Pain Control for the Child and Adolescent

McDonald¹,

Avery²,

Dean³

et al. 2011

McDonald and Avery Dentistry for the Child and Adolescent

View full text Add to dashboard Cite

“…The safety, but not the efficacy, of OraVerse has been evaluated in pediatric patients under the age of 6 years old. Dosages in pediatric patients may need to be limited based on body weight [13].…”

Section: Pediatric Usementioning

confidence: 99%

“…The pharmacokinetics of OraVerse after administration of more than 1 cartridge (0.4 mg) has not been studied in children [13].…”

Section: Pediatricsmentioning

confidence: 99%

OraVerse: Reverses Numbness After Dental Procedures

Prasanna

2012

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That's because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection -the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.

show abstract

Reversal of Soft-Tissue Local Anesthesia With Phentolamine Mesylate in Pediatric Patients

Cited by 53 publications

References 4 publications

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Local Anesthesia and Pain Control for the Child and Adolescent

OraVerse: Reverses Numbness After Dental Procedures

Contact Info

Product

Resources

About