OraVerse: Reverses Numbness After Dental Procedures

Prasanna, Jammula Surya

doi:10.1007/s12663-011-0318-6

Cited by 13 publications

(14 citation statements)

References 12 publications

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“…Phentolamine mesylate is a safe, injectable solution, packaged in individual cartridges and approved by the Food and Drug Administration for the reversal of anesthesia in the lips and tongue after use of LA-containing vasoconstrictors [5][6][7][8][9][10][11][12]. This drug has been previously used to aid the diagnosis of pheochromocytoma and treat erectile dysfunction, dermal necrosis, and several hypertension conditions [8,13,14].…”

Section: Introductionmentioning

confidence: 99%

“…However, phentolamine mesylate is a pregnancy risk category C drug, and whether the drug is secreted in breast milk in lactating patients is unknown. Therefore, its use is generally avoided to prevent potential adverse effects [12].…”

Section: Introductionmentioning

confidence: 99%

“…The terminal elimination half-life of phentolamine in the blood is approximately 2-3 hours. The pharmacokinetics of phentolamine mesylate in adults and children over 30 kg are similar after intraoral submucosal injection [3,7,12,13,15].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics

Gago-García

Barrilero-Martin

Alobera-Gracia

et al. 2021

J Dent Anesth Pain Med

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Background: To evaluate changes in the effectiveness of phentolamine mesylate in combination with different local anesthetics (LAs) and vasoconstrictors. A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of three different LAs: lidocaine 2% 1/80,000, articaine 4% 1/200,000, and bupivacaine 0.5% 1/200,000. Methods: We compared treatments administered to the mandible involving a LA blockade of the inferior alveolar nerve. Results were assessed by evaluating reduction in total duration of anesthesia, self-reported patient comfort using the visual analog pain scale, incidence rates of the most common adverse effects, overall patient satisfaction, and patient feedback. Results: The differences among the three groups were highly significant (P < 0.001); time under anesthesia was especially reduced for both the lip and tongue with bupivacaine. The following adverse effects were reported: pain at the site of the anesthetic injection (11.1%), headaches (6.7%), tachycardia (1.1%), and heavy bleeding after treatment (3.3%). The patients' feedback and satisfaction ratings were 100% and 98.9%, respectively. Conclusions: Efficient reversal of LAs is useful in dentistry as it allows patients to return to normal life more readily and avoid common self-injuries sometimes caused by anesthesia. Phentolamine mesylate reduced the duration of anesthesia in the three studied groups, with the highest reduction reported in the bupivacaine group (from 460 min to 230 min for the lip and 270 min for the tongue [P < 0.001]).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics

Gago-García

Barrilero-Martin

Alobera-Gracia

et al. 2021

J Dent Anesth Pain Med

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“…OraVerse is not indicted for children aged less than 6 years, or weighing less than 15 kg. It is also inadviseable to use it after invasive surgical procedures or endodontic treatments, where post-operative discomfort is expected [27].…”

Section: Gow-gates Nerve Blockmentioning

confidence: 99%

Local anesthetics and advances in their administration – an overview

Jung¹,

Rybak²,

Milner³

et al. 2017

J Pre Clin Clin Res.

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In dentistry nowadays, local anesthesia is the standard and the backbone for controlling pain Every year, researchers seek and develop new ways in which pain can be alleviated and managed better to ensure patient comfort by focusing on improving aspects such as anaesthetic agents, delivery devices and the techniques involved. The introduction of newer techniques assists dentists in providing enhanced pain relief with reduced pain from injection and fewer adverse reactions. Objective. The purpose of this overview is to highlight the mechanism and efficacy of certain anaesthetic agents, emphasizing complications associated with local anesthesia, as well as the modern techniques that have been developed to improve patient comfort and reduce pain while performing anaesthesia.

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“…Furthermore, Phentoaminemesylate breaks down through liver and the kidneys, so some adverse side-effects might occur like: Diarrhea, facial swelling, increased blood pressure or hypertension, reactions to injection site, jaw pain, oral pain, paresthesia, pruritus, tenderness, upper abdominal pain and vomiting. [ 16 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of a trial pharmaceutical solution on reversing sensations after using lidocain: An animal study

et al. 2015

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Introduction:Local anesthesia has a paramount role in any branches of medical sciences specially dentistry. Soft tissue irritations and lips biting are adverse side-effects in some cases. This study tried out to represent a new pharmaceutical solution in returning sensations faster.Materials and Methods:Five New Zealand laboratory rabbits were anesthetized with 1 cc Ketamine and Xilosine intramuscularly in thigh site. Electrodes were attached to the palms and wrists. Then, 0.2 cc lidocain 2% was injected in forearm origin in order to block median proximal nerve in both forelegs. The nerves conduction study (NCS) was recorded before and after lidocain injection, plus 30 min and once again 1 h after calcium gloconate 10%, dextrose 50%, citric acid solution injection. The recorded data were analyzed using Wilcoxon test and using SPSS software (version 11.5) at significant level of 0.05.Results:The NCS of left and right forearms was 1.4 ± 1.35 mV and 0.48 ± 0.45 mV. According to the statistical test, there was no significant difference between two groups (P > 0.05).Conclusion:Calcium gloconate 10%, dextrose 50%, citric acid solution did not reverse the effect of anesthetic drugs. Possible reasons were pressure to the nerves, which were caused by drug volume, and low sample size.

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OraVerse: Reverses Numbness After Dental Procedures

Cited by 13 publications

References 12 publications

Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics

Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics

Local anesthetics and advances in their administration – an overview

Effect of a trial pharmaceutical solution on reversing sensations after using lidocain: An animal study

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