Reversal of Soft-Tissue Local Anesthesia With Phentolamine Mesylate in Adolescents and Adults

Hersh, Elliot V.; Moore, Paul A.; Papas, Athena; Goodson, J. Max; Mavalta, Laura A.; Rogy, Siegfried; Rutherford, Bruce; Yagiela, John A.; Bennett, Jeffrey; Eggertsson, Hafsteinn; Jarrett, Jodie L.; Mau, Melissa S.; Boynes, Sean G.; Lemak, Anne L.; Zovko, Jayme; Krzesinski, Maribeth; Aboosi, O. Basil; Pinto, Andrés; Secreto, Stacey A.; Gallagher, Bridget; Rosenberg, Morton; Singh, Mabi; Pradhan, N.; Singh, Mukti; Raybould, Ted P.; Pfail, John; Valauri, David V.; Ivanova, Yordanka K.; Gordon, Sharon M.; Arribas, Alfredo; Sankar, Vidya; Luce, Ernest B.; Valdez, Ernest E.; Gonzales, Noemi C.; Henegar, Anthony; Schreiber, Andrea; Allen, Kenneth D.; Lopresti, James; Kreismann, Judith; Andrew, Margaret; Freer, George A.; McGavin, S.K.; Blissett, Georgia; McCallister, Pauline; Smith, Jodi D.; Beales, Kim; Giannobile, William V.; Kim, Amy S.; Snyder, Mark D.; Snow, Paul R.; Luo, Steven Y.; Robinson, Amanda L.; Peralta, Steffany; Hudson, Michelle; Kleven, Jacqueline; Tavares, Mary; Soncini, Jennifer; Chvetchkova, Maria; Roberts, Christine L.; Murray, Lora; Stultz, Jacyn; Floros, Constantinos; Hayashi, Christine M.; Torres, Indira; Parisi, Melinda; Goss, Jennifer S.; Shiba, Deborah

doi:10.14219/jada.archive.2008.0311

Cited by 49 publications

(45 citation statements)

References 10 publications

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“…Side effects have been reported as minimal and similar to a sham treatment (2)(3)(4)(5). Additionally, Hersh et al (3) found that recovery of subjects' perceptions of altered function, sensation, appearance, and actual function (speaking, smiling, drinking and drooling) was quicker with phentolamine than a sham treatment.…”

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confidence: 96%

“…For adults, the dosage is a cartridge of phentolamine (0.4 mg) given in the same location as the local anesthetic injection in a 1:1 ratio with a maximum dose of two cartridges (0.8 mg) (2). Phentolamine is a nonselective, alpha-adrenergic blocking agent that has been available in the United States since 1952 for the clinical reversal of accidental extravasation of catecholamines during intravenous administration and for the diagnosis of pheochromocytoma (2,3). The primary action of phentolamine is vasodilation (2)(3)(4).…”

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confidence: 99%

“…A number of well-controlled studies have shown that phentolamine statistically reduces the time of soft-tissue numbness when compared with a sham treatment (2)(3)(4)(5). Side effects have been reported as minimal and similar to a sham treatment (2)(3)(4)(5).…”

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confidence: 99%

See 2 more Smart Citations

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Fowler

Nusstein

Drum

et al. 2011

Journal of Endodontics

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mentioning

confidence: 96%

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confidence: 99%

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Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Fowler

Nusstein

Drum

et al. 2011

Journal of Endodontics

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“…In fact, this has occurred. 6 This alone would meet the above criteria, especially considering its potential direct application to all dental practitioners who administer local anesthetics.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Dentist Anesthesiologists to Dental Anesthesiology Research

Ganzberg

Rashid

Davidian³

2011

Anesthesia Progress

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In order to determine if dentist anesthesiologists ( DAs) actively contribute to research in the field of anesthesiology, and thus contribute new knowledge to the field, an extensive literature search was accomplished. DAs make up only 1.5% of dentists who actively contribute to anesthesia research but account for 10% of publications.To determine if the impact of DA research was similar to the American Dental Association (ADA) recognized specialties, h-indices of noted researchers in other specialties were compared to the h-indices of noted DA researchers.The results show that the impact of top DA researchers in dental anesthesiology is similar to the impact of top dental specialty researchers, despite lack of academic departments in dental schools where a large percentage of dental research is completed. Dentist anesthesiologists actively contribute to the research in anesthesiology for dentistry and thus, actively contribute to new knowledge in the field.

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“…Tachycardia and cardiac arrhythmias may occur with the use of phentolamine or other alpha-adrenergic blocking agents. Although such effects are uncommon after administration of OraVerse, clinicians should be alert to the signs and symptoms of these events, particularly in patients with a prior history of cardiovascular disease [6].…”

Section: Cardiovascular Eventsmentioning

confidence: 99%

OraVerse: Reverses Numbness After Dental Procedures

Prasanna

2012

J. Maxillofac. Oral Surg.

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The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That's because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection -the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.

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Reversal of Soft-Tissue Local Anesthesia With Phentolamine Mesylate in Adolescents and Adults

Cited by 49 publications

References 10 publications

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Reversal of Soft-tissue Anesthesia in Asymptomatic Endodontic Patients: A Preliminary, Prospective, Randomized, Single-blind Study

Contribution of Dentist Anesthesiologists to Dental Anesthesiology Research

OraVerse: Reverses Numbness After Dental Procedures

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