Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones

Abstract

These data suggest that while AIT-082 function is not dependent on adrenal hormones, it is modulated by them. That memory enhancement by AIT-082 was not inhibited by high plasma corticosterone levels may have positive implications for its clinical utility, given that many Alzheimer's disease patients have elevated plasma cortisol levels.

Role of Acetylcholinesterase Inhibitors and Alzheimer Disease

“…[ [131][132][133][134][135][136][137][138][139][140] Nefiracetam: (C14H18N2O2) N-(2,6dimethylphenyl)-2-(2-oxopyrrolidin-1yl)acetamide Comparisons were made from a total of 22 elderly patients.…”