Reversal of cognitive decline in Alzheimer's disease

Bredesen, Dale E.; Amos, Edwin C.; Canick, Jonathan; Ackerley, Mary; Raji, Cyrus A.; Fiala, Milan; Ahdidan, Jamila

doi:10.18632/aging.100981

Cited by 130 publications

(121 citation statements)

References 17 publications

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“…In the five case studies only three provided pre-post-test MMSE or similar which hindered comparison of clinical importance (Figure 4). The case studies in Bredesen et al (2016) reported over 10 instruments including magnetic resonance imaging (MRI) and fluorodeoxyglucose (FDG)-positron emission tomography (PET) scans, metabolic testing, quantitative neuropsychological testing, genetic testing and a battery of cognitive tests. Whilst three of these case studies reported pre-post-test MMSE, one (Patient 9) reported the Montreal Cognitive Assessment (MoCA) instead, which substituted for the MMSE in the ES analysis.…”

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confidence: 99%

A mixed methods systematic review of multimodal non-pharmacological interventions to improve cognition for people with dementia

2018

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Objective: Multimodal non-pharmacological interventions have been argued to have the potential to complement current pharmacological approaches to improving quality of life for people living with dementia. The aim of this review was to identify, synthesise and appraise the evidence for the effectiveness of multimodal non-pharmacological interventions for improving cognitive function specifically. Method: After a comprehensive search strategy including grey literature, 26 studies were reviewed. The inclusion criteria concerned adults with a primary diagnosis of dementia. Studies used two or more different modes of intervention, and measured a cognitive outcome. Due to differences in the conceptualisations of the term 'multimodal', a typology of modes and methods was developed to facilitate classification of candidate studies. Results: Twenty-one group studies and five case studies were found. Group studies used two or three modes of intervention and multiple methods to implement them. Interventions utilised were cognitive, physical, psychological and psychosocial, nutrition, fasting, gut health, sleep hygiene, stress reduction, detoxification, hormonal health and oxygen therapy. Five individual case studies were found in two separate papers. Each personalised patient treatment utilised in-depth assessments and prescribed up to nine different modes. In 19 (90%) of the 21 group comparisons, participants were reported to have cognitive improvements, stability with their

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confidence: 99%

A mixed methods systematic review of multimodal non-pharmacological interventions to improve cognition for people with dementia

2018

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“…Our previous work using a similar herbal formula called GAPT can markedly enhance learning and memory of AD rat models induced by Aβ injection or transgenic mice of APPV717I and APPs we/PS1dE9 [13], and also showed a significant improvement on cognitive function in patients with amnestic mild cognitive impairment, an early stage of AD (n = 101), consistently across different cognitive cales in a small sample of clinical trial [14]. The good effects of multiple combined therapy in treating MCI (mild cognitive impairment) and SCI (subjective cognitive impairment) and AD, was published by Dale E. Bredesen et al [15] [16]. A therapeutic approach characterized by programmatic, personalization, as well as dubbed metabolic enhancement for neurodegeneration (MEND protocol) was used.…”

Section: Discussionmentioning

confidence: 90%

A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years

Wei¹,

Zhang²,

Shi³

et al. 2017

WJNS

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Background: Although Alzheimer's disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia.

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“…There is now a growing awareness that comprehensive management of ill health requires multiple approaches including management of lifestyle factors. An example of the preliminary data showing signs of success using multiple approaches is the reversal of the cognitive decline in people with Alzheimer's and cognitive impairment, which includes an individualized, iterative, multi-pronged program including optimising biomarkers, nutritional supplements, fasting, exercise, brain stimulation, stress reduction and sleep optimization [81,82].…”

Section: Discussionmentioning

confidence: 99%

Can natural ways to stimulate the vagus nerve improve seizure control?

Yuen

Sander

2017

Epilepsy & Behavior

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The vagus nerve (VN) is the longest cranial nerve innervating the neck, thorax and abdomen, with afferent fibres transmitting a range of interoceptive stimuli and efferent fibres to somatic structures and autonomic preganglions. Over the last few decades, electrical stimulation of the VN using implanted devices (VNS) has been developed leading to its approval for the treatment of epilepsy and depression. More recently non-invasive devices to stimulation the VN have been developed. The VN has many functions and the activity that is most amenable to assessment is its effect in controlling the cardiac rhythm. This can be easily assessed by measuring heart rate variability (HRV). Decreased HRV is a result of poorer vagal parasympathetic tone and is associated with a wide range of ill health conditions including a higher risk of early mortality. People with epilepsy, particularly those with poorly controlled seizures have been shown to have impaired parasympathetic tone. So, might natural ways to stimulate the VN, shown to improve parasympathetic tone as indicated by increased HRV, improve seizure control? There are numerous natural ways that have been shown to stimulate the VN, improving HRV and hence parasympathetic tone. These natural ways fall mainly into 3 categories -stress reduction, exercise and nutrition. Though the natural ways to stimulate the VN have been shown to increase HRV, they have not been shown to reduce seizures. The exception is listening to Mozart's music which has been shown to increase parasympathetic tone and decrease seizures. Clearly much more work is required to examine the effect of the various ways to increase HRV on seizure occurrence.

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Reversal of cognitive decline in Alzheimer's disease

Cited by 130 publications

References 17 publications

A mixed methods systematic review of multimodal non-pharmacological interventions to improve cognition for people with dementia

A mixed methods systematic review of multimodal non-pharmacological interventions to improve cognition for people with dementia

A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years

Can natural ways to stimulate the vagus nerve improve seizure control?

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