Reveal the molecular mechanism of cosolvency behaviors of proline in alcohol + acetone binary mixed solvent

Molecular Mechanism of the Cosolvency Effect in Organic Solutes with Similar Structures

“…The results are shown in Figures and S7. In our previous work, the chemical shift of H atoms in β-proline was detected . And the results indicate that some H atoms in β-proline undergo a chemical shift toward lower field (higher chemical shift) initially as the methanol content increases.…”

“…In our previous work, the chemical shift of H atoms in β-proline was detected. 21 And the results indicate that some H atoms in βproline undergo a chemical shift toward lower field (higher chemical shift) initially as the methanol content increases. However, when the methanol content exceeds a certain value, the chemical shift of H atoms shifts toward higher field (lower chemical shift).…”

“…In-depth research and the rational application of cosolvecny have profound implications and important significance in chemical engineering fields such as purification and crystallization. − Cosolvency can also be used for the separation of chiral compound using ionic liquids . It also provides a new method for the development of high-performance materials. , Currently, an increasing number of cosolvency phenomena have been observed in many systems, which has attracted the widespread attention of researchers to explore its mechanism. ,,− Some researchers suggest that the generation of the cosolvency may be caused by the similarity between solvent and solute molecules or the preferential solvation by the solvents. ,, Nevertheless, a considerable number of researchers have proposed that the cosolvency effect was induced by the changes in the spatial conformation of the compound molecules caused by the solvent composition changes, altering the intermolecular interactions between solute and solvent molecules. − Moreover, in our previous studies, it was found that the cosolvency phenomenon of proline system is mainly attributed to the changes in the aggregate form of the l -proline molecules when varying the solvent composition, and the diverse form of aggregates can affect the intermolecular interactions between solute and solvent molecules with the changes in solution composition. − Although some scholars have conducted research on the solubility difference of solutes in binary mixed solvents with similar structure and it has been found that the molecular structure of solvents has a significant impact on the solubility performance of solutes, the general mechanism of cosolvency has not been completely revealed and understood.…”

Measurements and Correlation of Timolol Maleate Solubility in Biobased Neat and Binary Solvent Mixtures

“…Generally, cosolvency might be a result of the similarity between the solute and solvent molecules or preferential solvation of one of the solvents that leads to variations in solute−solvent interactions. 6,69,70 Based on the data presented in Figure 4, it can be concluded that 2-propanol is superior as an antisolvent compared to 2-MeTHF and DMI due to its enhanced impact on the solubility of TIM at all temperatures without cosolvency effects. Enantiomeric Purity Analysis.…”

“…Studying the root cause of the cosolvency effect of DMI goes beyond the scope of the study. Generally, cosolvency might be a result of the similarity between the solute and solvent molecules or preferential solvation of one of the solvents that leads to variations in solute–solvent interactions. ,, …”