Molecular Mechanism of the Cosolvency Effect in Organic Solutes with Similar Structures
Guoliang Zhu,
Hui Yu,
Qin Wang
et al.
Abstract:Cosolvency is an interesting and important solubilization strategy that can be reasonably utilized in the pharmaceutical industry and other industries. However, the molecular mechanism is not well understood. To explore the microscopic mechanism of the cosolvency, two organic small molecules (L-hydroxyproline and D-pipecolic acid) with very similar structures were selected as model compounds. Their solubility in three binary mixed solvents of alcohol + acetone (methanol + acetone, ethanol + acetone, and 1-prop… Show more
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