Revascularization Time in Liver Transplantation: Independent Prediction of Inferior Short- and Long-term Outcomes by Prolonged Graft Implantation

Abstract

Shorter graft revascularization is a protective factor in LT, particularly in the setting of graft marginality. Careful graft-recipient matching and emphasis on surgical expertise may aid in achieving better outcomes in LT.

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

“…Moreover, considering the scarcity of organ donations worldwide, it is of paramount importance to optimize the outcomes of organ transplants. Revascularization rates in liver transplants correlate with long term graft survival, renal function and early allograft dysfunction 53 and 017968). Bbs4 -/mice were generated in the Lupski lab and backcrossed to C57Bl/6J 54 .…”

Donor Hepatectomy and Implantation Time Are Associated With Early Complications After Liver Transplantation: A Single-center Retrospective Study

“…1,2 These findings were in part confirmed in 2 retrospective analyses outside the Eurotransplant region for donor hepatectomy and implantation time, respectively. 3,4 Despite the fact that early complications such as nonanastomotic biliary strictures (NAS) 5 and early allograft dysfunction (EAD) 6 are well-known to reduce long-term graft and patient survival, it is not known whether donor hepatectomy and implantation time also impact on these short-term outcomes. Indeed, as far as we are aware, no previous study has investigated the impact of both donor hepatectomy and implantation time on the risk of NAS.…”

Graft implantation in liver transplantation ‐ The clock is ticking

“…The nature of the graft insult during implantation is similar to that sustained during the donor warm ischaemic time (dWIT) in donation following circulatory death (DCD) and the retrieval hepatectomy [5,6]. Evidence that a prolonged rWIT has a negative effect on liver transplantation has been reported by other authors [6–9]. Al Kurdi et al report the novel finding that attainment of rWIT below a certain time threshold, ideally ≤30 minutes, improves short‐ and long‐term patient survival.…”