Donor Hepatectomy and Implantation Time Are Associated With Early Complications After Liver Transplantation: A Single-center Retrospective Study

Abstract

Jochmans are recipients of a CAF chair for abdominal transplant surgery. J. Pirenne is recipient of an IGL chair for abdominal transplant surgery. D. Monbaliu is a senior researcher of the research foundation Flanders (Fonds Wetenschappelijk Onderzoek -Vlaanderen, FWO), Belgium. The department of abdominal transplant surgery has received unrestricted grants from Astellas and Roche.

The effect of organ preservation solutions on short‐term outcomes after liver transplantation: a single‐center retrospective study

“…Nevertheless, the inverse probability of treatment weighting approach has accounted for baseline differences of these parameters sufficiently, allowing us to compare LTx with comparable duration of these surgical times (Table S3), thereby reducing their confounding effect. Furthermore, a recently performed retrospective analysis investigating the effect of donor hepatectomy and liver implantation time on the probability to develop EAD [23] showed that HTK is associated with the probability of this complication independently from the effect of all abovementioned surgical times, consistent with the findings reported herein.…”

“Time is tissue”—A minireview on the importance of donor nephrectomy, donor hepatectomy, and implantation times in kidney and liver transplantation

“…Adelmann et al showed an independent correlation between donor hepatectomy time in DBD and early graft function measured by the Model for Early Allograft Function score 22 . In our cohort, the risk of early allograft dysfunction was not influenced by donor hepatectomy time 23 . However, the odds of ischemic cholangiopathy increased by 19% per 10‐min increase in donor hepatectomy time 23 .…”

“…In our cohort, the risk of early allograft dysfunction was not influenced by donor hepatectomy time 23 . However, the odds of ischemic cholangiopathy increased by 19% per 10‐min increase in donor hepatectomy time 23 . Our Eurotransplant registry study showed donor hepatectomy time to be an independent predictor of overall graft failure 24 .…”

“…Implantation times of 40–45 min until portal reperfusion have been reported, with wide variation (Table 4). In our single‐center study, the odds of early allograft dysfunction independently increased by 26% for every 10 additional minutes to portal reperfusion 23 . The time between portal and hepatic artery reperfusion increased the odds of early allograft dysfunction by 13% per 10‐min increase 23 .…”

“…In our single‐center study, the odds of early allograft dysfunction independently increased by 26% for every 10 additional minutes to portal reperfusion 23 . The time between portal and hepatic artery reperfusion increased the odds of early allograft dysfunction by 13% per 10‐min increase 23 . In a United Network for Organ Sharing (UNOS) registry study, implantation time exceeding 70 min, in 10‐min tiers, was one of the factors that most significantly correlated with 90‐day mortality 26 .…”