Return of Human Corneal Sensitivity After Penetrating Keratoplasty

Mathers, William D.; Jester, James V.; Lemp, Michael A.

doi:10.1001/archopht.1988.01060130220030

Cited by 63 publications

(32 citation statements)

References 9 publications

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“…Here, traditional allografts containing donor cells were used, as is the case of human corneal transplantations that the implants are designed to replace. This corresponds to reports where nerve in-growth and touch sensitivity recovers slowly (Ͼ18 mo after laser refractive eye surgery; Ͼ10 yr after LKP) after human corneal wounding or transplantation (33,34). Our result, therefore, represents a dramatic advance over the slow nerve regeneration after current human donor allograft therapy (34) and a demonstration of in vivo nerve regeneration in the cornea promoted by a fabricated material.…”

Section: Discussionsupporting

confidence: 39%

Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation

Li¹,

Carlsson²,

Lohmann³

et al. 2004

American Journal of Ophthalmology

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Our objective was to determine whether key properties of extracellular matrix (ECM) macromolecules can be replicated within tissue-engineered biosynthetic matrices to influence cellular properties and behavior. To achieve this, hydrated collagen and Nisopropylacrylamide copolymer-based ECMs were fabricated and tested on a corneal model. The structural and immunological simplicity of the cornea and importance of its extensive innervation for optimal functioning makes it an ideal test model. In addition, corneal failure is a clinically significant problem. Matrices were therefore designed to have the optical clarity and the proper dimensions, curvature, and biomechanical properties for use as corneal tissue replacements in transplantation. In vitro studies demonstrated that grafting of the laminin adhesion pentapeptide motif, YIGSR, to the hydrogels promoted epithelial stratification and neurite in-growth. Implants into pigs' corneas demonstrated successful in vivo regeneration of host corneal epithelium, stroma, and nerves. In particular, functional nerves were observed to rapidly regenerate in implants. By comparison, nerve regeneration in allograft controls was too slow to be observed during the experimental period, consistent with the behavior of human cornea transplants. Other corneal substitutes have been produced and tested, but here we report an implantable matrix that performs as a physiologically functional tissue substitute and not simply as a prosthetic device. These biosynthetic ECM replacements should have applicability to many areas of tissue engineering and regenerative medicine, especially where nerve function is required.regenerative medicine ͉ tissue engineering ͉ cornea ͉ implantation ͉ innervation

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Section: Discussionsupporting

confidence: 39%

Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation

Li¹,

Carlsson²,

Lohmann³

et al. 2004

American Journal of Ophthalmology

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“…Previous IVCM studies show a complete absence of sub-basal nerves in a high proportion of grafts up to 31 years after PK (26)(27)(28)(29), and contact aesthesiometry studies have revealed that grafts remain anaesthetic up to 32 years after PK (26,30,31).…”

Section: Discussionmentioning

confidence: 43%

A Biosynthetic Alternative to Human Donor Tissue for Inducing Corneal Regeneration: 24-Month Follow-Up of a Phase 1 Clinical Study

et al. 2010

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“…As magnitude of the surgical injury depends on pterygium dimensions, a variable number of corneal nerves could be discontinued in any case and, therefore, the time for complete CS recovery could be longer or shorter. Several studies have reported a significant relationship between the depth of the dissection in a surgical procedure and the time for complete CS recovery [25][26][27][28] . In addition, the ideal time to operate the eyes 12 with pterygium seems to be related with small lesions not only because the CS recovery could be faster but also because final astigmatism seems to be lower 29 .…”

Section: Discussionmentioning

confidence: 47%

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

Julio

Campos

Pujol

et al. 2016

Cornea

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Purpose: To establish determining factors for fast corneal sensitivity (CS) recovery after pterygium excision.Methods: Thirty-two eyes of 14 males and 18 females with primary nasal pterygium were recruited. Differences in CS (in the four quadrants and the center using Cochet-Bonnet esthesiometer), pterygium corneal area (PCA), tear osmolarity, tear break up time, Schirmer test, and ocular symptoms were analyzed before and 1 month after lesion excision. The relationship between CS recovery (difference between the two time points; CS1-CS0) and the other features was assessed.Results: All the studied locations exhibited normal (6 cm) or near normal mean CS at the 2 time points, except tendency for moderate hypoesthesia in nasal CS0 (median 4.5; range: 1.5 -6.0 cm). Point by point comparison revealed significant postoperative improve in nasal location (p=0.008; Wilcoxon rang test) with normal values in 17 eyes (53%) and a median CS1= 5.0 cm (2.5 -5.5 cm) in 15 eyes with no complete recovery. No significant correlation was found between CS0 and the studied variables and CS1 was only significantly correlated with PCA (rho: -0.441; p<0.05). CS recovery also showed significant correlation with PCA (rho= -0.516; p<0.01). Conclusions:Corneal sensitivity recovery after pterygium excision showed important variability and the only studied factor that seems to be determinant could be PCA. It would be advisable to operate while lesion is relatively small, with lower surgical injury, and faster and complete recovery, thus protecting ocular surface homeostasis.3

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Return of Human Corneal Sensitivity After Penetrating Keratoplasty

Cited by 63 publications

References 9 publications

Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation

Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation

A Biosynthetic Alternative to Human Donor Tissue for Inducing Corneal Regeneration: 24-Month Follow-Up of a Phase 1 Clinical Study

Determining Factors for Fast Corneal Sensitivity Recovery After Pterygium Excision

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