Retrovirus-Like Sequences in Graves' Disease: Implications for Human Autoimmunity

Ciampolillo, Anna; Mirakian, Rita; Schulz, Thomas F.; Marini, Vittoria; Buscema, Massimo; Pujol-Borrell, Ricardo; Bottazzo, Gian Franco

doi:10.1016/s0140-6736(89)92382-9

Cited by 110 publications

(38 citation statements)

References 27 publications

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“…Evidence implicating HTLV-I in multiple sclerosis has been reported (29,301, and HTLV-I has been isolated from the cerebrospinal fluid of a patient with spastic paralysis (31). Recent studies using Southern hybridization with an HIV-1 gag probe yielded evidence for retroviral sequences in SLE serum (32) and in thyroid glands removed from patients with Graves' disease (33). However, at minimum, a virus must be isolated from tissues before a definitive association of retrovirus TALAL ET AL infection with any chronic autoimmune disease can be considered to exist.…”

Section: Resultsmentioning

confidence: 99%

Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)

Talal

Dauphinée

Dang

et al. 1990

Arthritis & Rheumatism

215

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Primary Sjögren's syndrome (SS) is considered a benign autoimmune disease; it is characterized by lymphoid infiltration of salivary and lacrimal glands, often accompanied by the presence of serum autoantibodies, particularly anti‐Ro (SS‐A) and anti‐La (SS‐B). There are important immunologic similarities between primary SS and acquired immunodeficiency syndrome. To investigate for a possible immune response to retroviral proteins in primary SS, we performed immunoblotting against human immunodeficiency virus‐1 (HIV‐1) proteins using sera from 47 patients with primary SS. Moderate‐to‐strong reactivity, suggesting the presence of serum antibodies, was found in 14 patients (30%). Of 120 normal subjects, only 1 showed moderate positivity. All 14 positive SS sera reacted against p24 (gag) but failed to react against gp41 or gp120 (env). This response did not reflect hypergammaglobulinemia since immunoglobulin concentrations among the 29 SS patients studied were the same in sera that contained and sera that did not contain anti‐gag reactivity. Two sera also reacted against p17 gag. Four reacted against HIV‐2 core proteins, but none reacted with core proteins of human T lymphotropic virus‐I. Only 1 of the 14 sera reacted against Ro (SS‐A), and 1 other reacted against La (SS‐B). These results identify a subset of SS patients characterized by 1) the presence of serum antibodies to HIV‐1 group‐specific, but not type‐specific, proteins, and 2) the relative absence of anti‐Ro (SS‐A) and anti‐La (SS‐B) autoantibodies. In this latter respect, these SS patients constitute a subpopulation that resembles patients with HIV‐induced SS‐like disease.

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Section: Resultsmentioning

confidence: 99%

Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)

Talal

Dauphinée

Dang

et al. 1990

Arthritis & Rheumatism

215

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“…The reason for this overexpression/presentation is not yet clear. Viral infection has been shown to stimulate the metabolic functions of fibroblasts (34), and retroviruses have been mentioned frequently in the context of thyroid autoimmunity (35)(36)(37)(38). Thus, it is tempting to speculate that viral infection may also be of importance in endocrine ophthalmopathy.…”

Section: Discussionmentioning

confidence: 99%

Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts.

Grubeck‐Loebenstein¹,

Trieb²,

Sztankay³

et al. 1994

J. Clin. Invest.

143

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“…Reports of retrovirus-like particles in Sjogren's syndrome (Garry et al, 1990) and sequences in Graves' disease (Ciampolillo et al, 1989) and multiple sclerosis (Kurth, 1986) suggest that their expression may have considerable impact on the immune system.…”

Section: Introductionmentioning

confidence: 99%

Expression of novel transposon-containing mRNAs in human T cells

Wilkinson²,

Jd³

et al. 1996

Journal of General Virology

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Retrovirus-Like Sequences in Graves' Disease: Implications for Human Autoimmunity

Cited by 110 publications

References 27 publications

Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)

Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)

Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts.

Expression of novel transposon-containing mRNAs in human T cells

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