Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Abstract

The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIVÀ (n = 537) patients with monoclonal gammopathies. HIV+ and HIVÀ patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIVÀ SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIVÀ (6.4% vs 15.4%, p < 0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

Pancytopenia as the main manifestation of human immunodeficiency virus infection in the AIDS stage

“…Monoklonální gamapatie nejasného významu je u osob infikovaných HIV relativně častým jevem, údaje o riziku progrese do plazmocelulární neoplazie se v jednotlivých studiích liší (8)(9)(10).…”