Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France

Germain, Nicolas; Herwegh, Stéphanie; Hatzfeld, Anne-Sophie; Bocket, Laurence; Prevost, Brigitte; Danzé, Pierre‐Marie; Marchetti, Philippe

doi:10.1007/s10561-021-09901-3

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Many studies have sought to define the antibody response following SARS-CoV-2 infection ( 14 , 15 ). These include studies on hospitalized COVID-19 patients ( 16 – 19 ), asymptomatic individuals ( 20 , 21 ), and retrospective serological studies ( 22 – 25 ). The vast majority of infected individuals seroconvert and generate IgA, IgM, and IgG-specific antibodies within 3 weeks of infection ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Durable Antibody Responses in Staff at Two Long-Term Care Facilities, during and Post SARS-CoV-2 Outbreaks

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Durable Antibody Responses in Staff at Two Long-Term Care Facilities, during and Post SARS-CoV-2 Outbreaks

et al. 2021

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“…For articles published after late 2020, the age ranges were narrower than in articles published at the beginning of the pandemic. Since the emergence of the virus, young populations have also been found to have high seroprevalence and should not be overlooked [40,96]. The impact of social disadvantage was documented in the general population and blood donors in a comparison of seroprevalence according to income [32,47,68,104,126,[129][130][131][132][133][134] or education level [18,19,20,47,48,53,57,68,82,99,[130][131][132][133][134][135][136][137][138].…”

Section: Plos Onementioning

confidence: 99%

Seroprevalence and SARS-CoV-2 invasion in general populations: A scoping review over the first year of the pandemic

et al. 2023

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Since the beginning of the COVID-19 pandemic, counting infected people has underestimated asymptomatic cases. This literature scoping review assessed the seroprevalence progression in general populations worldwide over the first year of the pandemic. Seroprevalence studies were searched in PubMed, Web of Science and medRxiv databases up to early April 2021. Inclusion criteria were a general population of all ages or blood donors as a proxy. All articles were screened for the title and abstract by two readers, and data were extracted from selected articles. Discrepancies were resolved with a third reader. From 139 articles (including 6 reviews), the seroprevalence estimated in 41 countries ranged from 0 to 69%, with a heterogenous increase over time and continents, unevenly distributed among countries (differences up to 69%) and sometimes among regions within a country (up to 10%). The seroprevalence of asymptomatic cases ranged from 0% to 31.5%. Seropositivity risk factors included low income, low education, low smoking frequency, deprived area residency, high number of children, densely populated centres, and presence of a case in a household. This review of seroprevalence studies over the first year of the pandemic documented the progression of this virus across the world in time and space and the risk factors that influenced its spread.

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Durable antibody responses in staff at two long-term care facilities, during and post SARS-CoV-2 outbreaks

Gallichotte

Nehring

Young

et al. 2021

Preprint

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SARS-CoV-2 has had a disproportionate impact on non-hospital healthcare settings such as long-term care facilities (LTCFs). The communal nature of these facilities, paired with the high-risk profile of residents, has resulted in thousands of infections and deaths and a high case fatality rate. To detect pre-symptomatic infections and identify infected workers, we performed weekly surveillance testing of staff at two LTCFs which revealed a large outbreak at one of the sites. We collected serum from staff members throughout the study and evaluated it for binding and neutralization to measure seroprevalence, seroconversion, and type and functionality of antibodies. At the site with very few incident infections, we detected that over 40% of the staff had preexisting SARS-CoV-2 neutralizing antibodies, suggesting prior exposure. At the outbreak site, we saw rapid seroconversion following infection. Neutralizing antibody levels were stable for many weeks following infection, suggesting a durable, long-lived response. Receptor-binding domain antibodies and neutralizing antibodies were strongly correlated. The site with high seroprevalence among staff had two unique introductions of SARS-CoV-2 into the facility through seronegative infected staff during the period of study but these did not result in workplace spread or outbreaks. Together our results reveal that high seroprevalence rate among staff can contribute to herd immunity within a workplace and protect against subsequent infection and spread within a facility.

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Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France

Cited by 3 publications

References 18 publications

Durable Antibody Responses in Staff at Two Long-Term Care Facilities, during and Post SARS-CoV-2 Outbreaks

Durable Antibody Responses in Staff at Two Long-Term Care Facilities, during and Post SARS-CoV-2 Outbreaks

Seroprevalence and SARS-CoV-2 invasion in general populations: A scoping review over the first year of the pandemic

Durable antibody responses in staff at two long-term care facilities, during and post SARS-CoV-2 outbreaks

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