Retrospective Evaluation of Patient Compliance in Continuous Oxygen Therapy

Abstract

Background: Prescription of continuous oxygen therapy (COT) for correct indications, adequate education of the patients, and a regular and sufficient oxygen intake are essential. Objective: To evaluate the indications of COT prescriptions in six different centers around Istanbul and patient compliance. Methods: The initial data of the cases were taken from hospital records and throughout the study personal visits were done as well as arterial blood gas (ABG) analyses. Results: 86 patients out of 110 (78.1%) were found to be eligible candidates for COT. Daily duration of therapy was more than 15 h in 55 (43.3%) and more than 12 h in 14 (11%) of the cases. During therapy, mean PaO₂ values have increased from 52.1 ± 11 to 58.6 ± 12 mm Hg (p < 0.001), while mean PaCO₂ values have decreased from 50.16 ± 9.6 to 48.02 ± 9 mm Hg (p < 0.05). 98 of the cases (77.1%) stated that they had benefited from the therapy. Conclusions: We conclude that COT is an effective treatment modality, but patient compliance remains a problem.

How do respiratory patients perceive oxygen therapy? A critical interpretative synthesis of the literature

“…Fear of dependency was a recurring theme. Authors make reference to patients not using prescribed oxygen due to their fear of addiction 52 and the perception that others have of them whilst wearing the oxygen in public, ‘Wearing an oxygen cannula just looks like someone addicted to drugs…’. 34 This can be related to non-compliance, with reports of 20% of patients using oxygen for fewer hours than prescribed as a result of fear of addiction.…”

“…Fear of dependency was a recurring theme. Authors make reference to patients not using prescribed oxygen due to their fear of addiction 52 and the perception that others have of them whilst wearing the oxygen in public, 'Wearing an oxygen cannula just looks like someone addicted to drugs . .…”

A Tailor‐Made Chimeric Thiamine Diphosphate Dependent Enzyme for the Direct Asymmetric Synthesis of (S)‐Benzoins

“…Whereas enzymes are available for the enantiocomplementary synthesis of a broad range of symmetrical and mixed aliphatic, araliphatic, and aromatic products,2 so far no biocatalyst is available to selectively access ( S )‐benzoins starting from benzaldehydes. Instead, other enzymatic routes became available, which involve kinetic resolution as well as deracemization of rac ‐ benzoins,3 or asymmetric reduction of 1,2‐diarylethane‐1,2‐diones (benzils) 4. Although these approaches are mostly characterized by high stereoselectivity, they all share the same drawback: the racemic or prochiral starting material must be chemically synthesized beforehand.…”

Ein maßgeschneidertes chimäres Thiamindiphosphat‐abhängiges Enzym zur direkten asymmetrischen Synthese von (S)‐Benzoinen

“…Während Enzyme für die enantiokomplementäre Synthese einer breiten Palette von symmetrischen und gemischten aliphatischen, araliphatischen und aromatischen Produkten vorliegen,2 ist bislang kein Biokatalysator für den selektiven Zugang zu ( S )‐Benzoinen ausgehend von Benzaldehyden verfügbar. Stattdessen stehen andere enzymatische Synthesewege zur Verfügung, darunter die kinetische Racematspaltung sowie Deracemisierung von rac ‐ Benzoinen3 oder die asymmetrische Reduktion von 1,2‐Diarylethan‐1,2‐dionen (Benzile) 4. Zwar sind diese Ansätze meist durch hohe Stereoselektivitäten charakterisiert, sie haben jedoch alle denselben Nachteil: Das racemische oder prochirale Ausgangsmaterial muss zunächst chemisch synthetisiert werden.…”