Retrospective diagnosis of hypoxic myocardial injury in premature newborns

Szymankiewicz, Marta; Matuszczak-Wleklak, Marzena; Vidyasagar, Dharmapuri; Gadzinowski, Janusz

doi:10.1515/jpm.2006.040

Cited by 26 publications

(21 citation statements)

References 22 publications

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“…Cardiac involvement associated with hypoxia in newborns occur in about 29% of asphyxiated infants (MartinAncel et al, 1995). Many studies indicated that infants with perinatal asphyxia and RDS develop myocardial damage (Tapia-Rombo et al, 2000;Trevisanuto et al, 2000a,b;Szymankiewicz et al, 2006). Unfortunately, there is no information about myocardial damage associated with hypoxia in premature calves with RDS.…”

Section: Discussionmentioning

confidence: 99%

Cardiac biomarkers in premature calves with respiratory distress syndrome

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Güzelbekteş

et al. 2016

Acta Veterinaria Hungarica

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The aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO 2 , O 2 saturation and high pCO 2 values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.

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Section: Discussionmentioning

confidence: 99%

Cardiac biomarkers in premature calves with respiratory distress syndrome

Aydoğdu

Yıldız

Güzelbekteş

et al. 2016

Acta Veterinaria Hungarica

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“…This parameter is often depressed after birth asphyxia and is a useful marker of severity and a prognostic indicator in asphyxia (16). In addition, troponin T, a marker of cardiac injury, was measured (1,17). To assess activation or suppression of mitochondrial apoptotic and survival pathways in myocardial left ventricular tissue, the protein level of apoptosis executioner cysteinyl aspartate-specific protease-3 (caspase-3) was determined.…”

Section: Articles Seehase Et Almentioning

confidence: 99%

“…ulti-organ dysfunction is a common outcome of severe perinatal asphyxia (1,2). One of the organs significantly involved in the fate of the asphyctic newborn is the heart (3,4); it can compromise the oxygen supply of other organs, resulting in irreversible injury (5).…”

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confidence: 99%

Propofol administration to the fetal–maternal unit reduces cardiac injury in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest

et al. 2013

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Background: cardiac dysfunction is reported to occur after severe perinatal asphyxia. We hypothesized that anesthesia of the mother with propofol during emergency cesarean section (c-section) would result in less cardiac injury (troponin T) in preterm fetuses exposed to global severe asphyxia in utero than anesthesia with isoflurane. We tested whether propofol decreases the activity of proapoptotic caspase-3 by activating the antiapoptotic AKT kinase family and the signal transducer and activator of transcription-3 (sTAT-3). Methods: Pregnant ewes were randomized to receive either propofol or isoflurane anesthesia. A total of 44 late-preterm lambs were subjected to in utero umbilical cord occlusion (UcO), resulting in asphyxia and cardiac arrest, or sham treatment. After emergency c-section, each fetus was resuscitated, mechanically ventilated, and supported under anesthesia for 8 h using the same anesthetic as the one received by its mother. results: At 8 h after UcO, the fetuses whose mothers had received propofol anesthesia had lower plasma troponin T levels, and showed a trend toward a higher median left ventricular ejection fraction (LVeF) of 84% as compared with 74% for those whose mothers had received isoflurane. Postasphyxia activation of caspase-3 was lower in association with propofol anesthesia than with isoflurane. Postasphyxia levels of sTAT-3 and the AKT kinase family rose 655% and 500%, respectively with the use of propofol anesthesia for the mother. conclusion: The use of propofol for maternal anesthesia results in less cardiac injury in late-preterm lambs subjected to asphyxia than the use of isoflurane anesthesia. The underlying mechanism may be activation of the antiapoptotic sTAT-3 and AKT pathways. Multi-organ dysfunction is a common outcome of severe perinatal asphyxia (1,2). One of the organs significantly involved in the fate of the asphyctic newborn is the heart (3,4); it can compromise the oxygen supply of other organs, resulting in irreversible injury (5). It is therefore important to maintain adequate cardiac function in neonates who have undergone an asphyxic insult. Currently, the only available therapy for cardiac function in the neonatal setting after an ischemic insult consists in treatment with positive inotropic and/or vasoactive drugs. The impact of this measure is limited because it neither prevents nor attenuates the degree of the initial myocardial ischemic injury (6,7). Evidence has now accumulated that some anesthetics such as propofol are cardioprotective in adult patients exposed to myocardial ischemia (8)(9)(10), and that this propofol-related cardioprotection is mediated through the activation of signal transducer and activator of transcription (STAT)-3 and phosphoinositide-3-kinase/AKT (11). Isoflurane, a volatile anesthetic, also protects the adult heart from ischemia and reperfusion injury by intervening with the mitochondrial apoptosis pathway (12,13). Both anesthetics are rapid acting and reliable and are therefore used when prompt delivery of the fetus becomes e...

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“…renatal asphyxia can affect all organs due to poor perfusion and reduced oxygen delivery, but the most detrimental effects are observed in the central nervous and cardiovascular system (1)(2)(3)(4)(5). Therefore, it is not surprising that asphyxia is the third major cause of neonatal mortality and accounts for more than one million neonatal deaths worldwide per year (6).…”

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confidence: 99%