Retrospective determination of regenerated nerve agent sarin in human blood by liquid chromatography–mass spectrometry and in vivo implementation in rabbit

Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification

“…To improve the mass spectrometric response of GB generated by fluoride-induced reactivation, Blanca et al . presented a derivatization procedure using 2-[(dimethylamino)methyl]phenol to yield its corresponding phosphonylated derivative that was analyzed by LC-ESI MS/MS [85] . In comparison to GC–MS methods typically used for the measurement of reactivated GB, this novel procedure turned out to be advantageous with respect to sensitivity, specificity and run time.…”

A novel approach for the detection and identification of sulfur mustard using liquid chromatography–electrospray ionization–tandem mass spectrometry based on its selective oxidation to sulfur mustard monoxide with N‐iodosuccinimide

“…A simple derivatization reaction for the detection and identification of G-nerve agents (GB, GD, GF, and GA) by LC-ESI-MS/MS or by direct ESI-MS/MS was previously developed. [24][25][26][27][28][29] Hence, we were highly motivated to develop a chemical derivatization reaction for the detection and identification of HD by LC-ESI-MS/MS.…”

“…HD is hardly soluble in water, and when dissolved, it dissociates rapidly and is not well ionized by ESI; therefore, its direct analysis by LC‐MS is challenging. A simple derivatization reaction for the detection and identification of G‐nerve agents (GB, GD, GF, and GA) by LC‐ESI‐MS/MS or by direct ESI‐MS/MS was previously developed 24–29 . Hence, we were highly motivated to develop a chemical derivatization reaction for the detection and identification of HD by LC‐ESI‐MS/MS.…”

A novel approach for on-site screening of organophosphorus nerve agents based on DTNB modified AgNPs using surface-enhanced Raman spectrometry

“…Various methods or devices have been used to detect OPNAs, such as LC-MS, [5][6][7][8] GC-MS or portable gas chromatographs, 9,10 ion mobility spectrometers (IMSs), 11 gas detection tubes, 12 enzyme inhibition assay (EIA), 13 enzyme-linked immunoassay (ELISA) and colorimetric methods. 14,15 Among all reported detection methods, EIA is still one of the most important tools for the conrmation of OPNA poisoning, forensic investigation, occupational health screening and therapeutic monitoring of intoxicated patients.…”