Retrospective cohort study of pregnancy outcomes in hidradenitis suppurativa

Abstract

side-effects and/or fear of relapse remained stable during patients' follow-up. Unexpectedly, the TABQOL scores measured at the time of inclusion of the population of prevalent patients, and at month 6 in incident cases, were not significantly different between patients taking topical corticosteroids, oral prednisone and/or immunomodulators, or immunosuppressants (P = 0Á96 and P = 0Á56, respectively). Overall, this large multicentre study provides evidence that the ABQOL score is a robust tool, sensitive to change, that assesses quality of life in patients with autoimmune bullous disease. As in many other diseases, quality-of-life questionnaires in autoimmune bullous dermatoses are poorly correlated with OSS, even in patients with high disease activity at the time of diagnosis. The close correlations between ABQOL and both DLQI and Skindex raise the question of its advantage over these scores. We have not been able to show its superiority in patients with mucosal damage. TABQOL is not sensitive to change. Unexpectedly, it does not seem to be correlated with the type of treatment.

Quality-of-life endpoints in women of childbearing age with hidradenitis suppurativa: a tertiary-care-centre-based study

“…12,13,16,29 What is more, lesions on the breasts can hinder lactation, which is why they should be treated timely. 11,12 There is also evidence that women with HS fear their child will have the disease, or delivery will be more di cult because of it. 22 Our study showed that most women worry about potential di culties during pregnancy and the postpartum, including whether they will be t enough to properly take care of their children.…”

“…Aside from the detrimental disease symptoms and sequalae common to both men and women, the latter also face di culties germane to their gender, such as menstruation-related ares, adverse pregnancy outcomes, limitations regarding treatment during pregnancy and the postpartum, birth and breastfeeding challenges, issues with pelvic examination, as well as breast examination and imaging tests. 2,10,[12][13][14][15][16] What is more, women seem to fare worse on quality-of-life endpoints comparing to their male counterparts: their overall sexual impairment is greater, they are more likely to have body image issues, have greater fear of rejection when it comes to relationships and manifest signi cantly more symptoms of depression. 5,[17][18][19][20] The impact of HS is felt by patients' families as well.…”

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

“…Higher BMI in women with fulfilled reproductive desires may be explained by their older age, as BMI is positively correlated with age [46], and the increasing weight gain between consecutive pregnancies, even in women without pre-existing obesity [47]. Weight gain is known to contribute to HS pathogenesis [48], while the effect of pregnancy on HS [49] as well as the effect of HS on pregnancy are unknown [50,51]. Although a high rate of HS exacerbation during pregnancy and postpartum has been reported, most patients did not receive HS-directed medical treatment or care from a dermatologist during their pregnancy [51].…”

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

“…The researchers found that rates of live births, likelihood of caesarean section and increased risk of gestational hypertension, preeclampsia, pregnancy complication or neonatal complication were not significantly associated with baseline HS severity. Interestingly, they observed (i) that in more than 10% of pregnancies women continued to use tobacco or marijuana during pregnancy, (ii) that the proportion of non-breastfeeding women was significantly higher in patients with HS breast lesions compared to those without HS breast lesions ( Figure 2 ) and (iii) significantly higher average rates of gestational hypertension and pre-eclampsia compared to the US general population [ 152 ].…”

“…Abbreviation: HS, hidradenitis suppurativa. Information extracted from references [ 72 , 86 , 87 , 112 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 152 , 157 , 158 , 168 , 169 , 173 , 174 ].…”