Retrospective analysis of therapeutic effect and prognostic factors on early glottic carcinoma

Peng, Zhongzhong; Li, Yanbing; Jin, Longwei; Tao, Xiaopeng; Cai, Xiaojun; Feng, Jieni; Liu, Rengeng; Zhang, Qianyu; Li, Libo

doi:10.1016/j.pdpdt.2016.06.008

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Among LSCCs, glottic cancer is the most common subtype, accounting for 80% of LSCC patients in the current study. Several studies have concluded that surgery is associated with a higher survival in patients with LSCCs, while there are a number of studies that have reported the opposite results; however, most of these studies were based on <100 patients . In a large meta‐analysis that included 562 participants treated with laser surgery and 706 participants treated with radiotherapy, the pooled analysis showed that laser surgery significantly improved the overall survival of patients with T1 glottic carcinoma group .…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

et al. 2018

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There are conflicting reports about whether radiotherapy or surgery is optimal for early‐stage laryngeal squamous cell carcinoma (LSCC), although both have recently been recommended. Patients with T1‐2N0M0 LSCC in the population‐based SEER database who underwent radiotherapy or surgery were reviewed. Propensity score matching was used to eliminate the baseline variations. After matching, 1913 pairs of patients were included. Overall, patients who received radiotherapy had worse cancer‐specific survival than patients with surgery. After stratification, the survival in patients who received radiotherapy was worse with respect to the following characteristics: ≤60 years of age; T1a glottis cancer; well‐differentiated tumors; and with married status. In other patients, survival outcomes were similar in patients who received radiotherapy and underwent surgery. Our results indicate that radiotherapy is not preferable in early‐stage LSCC patients who are ≤60 years of age, have T1a glottis cancer or well‐differentiated tumors, or are married. In other patients, both radiotherapy and surgery are comparable. However, our results cannot be a reference before controlled, prospective trials are performed.

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Section: Discussionmentioning

confidence: 99%

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

et al. 2018

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“…PDT is curative for early‐stage laryngeal cancer and can preserve laryngeal function without laryngectomy . Nine of our 10 patients with laryngeal SCCs (90%) achieved temporary CR, although four of the nine (44.4%) developed local recurrence after CR.…”

Section: Discussionmentioning

confidence: 87%

Photodynamic therapy in patients with head and neck squamous cell carcinoma

Hosokawa

Takebayashi²,

Takahashi³

et al. 2018

Lasers Surg Med

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“…Glottic SCC has a good prognosis due to early presentation because of voice change and early treatment [5]. Treatment aims at cure, laryngeal function preservation with optimal voice quality, swallowing and breathing functions [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcome of Definitive Radiotherapy and/or Surgery in T1-2N0M0 Glottic Squamous Cell Carcinoma: A Single Institution Retrospective Report

Ibrahim¹,

Askoura²,

Aleem³

2018

JCT

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Background: The current treatment options of early glottic carcinoma are radiotherapy; trans laser microsurgery, and open surgery. However, the best treatment is still controversial due to lack of randomized controlled trials. We aimed to evaluate the treatment results and the prognostic factors of local control of early glottic squamous cell carcinoma patients (GSCC) T1-2N0M0 treated at our institution. Material and Methods: We retrospectively studied the charts of 52 patients with early GSCC T1-T2N0M0 from 2010-2015 at the Clinical Oncology Department, Ain-Shams University. 24 patients had T1 and 28 had T2 early glottic carcinoma. The overall survival OS, local control rate, and laryngeal preservation rate were evaluated. Kaplan-Meier method, Cox proportional hazards model were used to analyze the data. Results: Median duration of follow-up was 13 months. Thirty-eight patients received radiation treatment alone (73.1%), 7.7% of the patients underwent surgery alone, and 19.2% of the patients had surgery combined with radiotherapy. Local recurrence after radiation failure developed in 6/52 patients, all had T2 disease and were salvaged by total laryngectomy. The ultimate local control rate was 88.5%, and the ultimate laryngeal preservation rate was 77.2% (40/52 patients). The median OS of the 52 patients was 13 months (range 2-46 months). Univariate analysis of factors associated with poor local control showed that age > 60 years was the only significant factor (P = 0.048). Conclusion: Radiotherapy achieves high local control and laryngeal preservation rates for patients with early glottic carcinoma, and is associated with a low rate of severe complications compared to surgery. Salvage surgery is feasible after radiotherapy failure.

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Retrospective analysis of therapeutic effect and prognostic factors on early glottic carcinoma

Cited by 9 publications

References 10 publications

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

Photodynamic therapy in patients with head and neck squamous cell carcinoma

Clinical Outcome of Definitive Radiotherapy and/or Surgery in T1-2N0M0 Glottic Squamous Cell Carcinoma: A Single Institution Retrospective Report

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