Retrospective analysis of pemphigoid gestationis in 32 Saudi patients – Clinicopathological features and a literature review

Pemphigoid gestationis: Clinical and histologic features of twenty-three patients

“…Although most patients’ symptoms spontaneously resolve after pregnancy, peripartum flare and continued symptoms during the postpartum period have also been reported (Cianchini et al, 2007). The disease course has also been reported to become more serious during subsequent pregnancies (Al-Saif et al, 2016). …”

Pemphigoid gestationis: current perspectives

“… 2 The tendency for onset late in pregnancy was also confirmed in a third study from Saudi Arabia including 32 patients which showed that 84% of women had onset of PG during the second or third trimester. 11 Finally, in a smaller study from the UK including 15 cases of PG, 8 women had onset in the third trimester, 2 in the immediate postpartum period, whereas 4 presented in the second trimester. 19 …”

“… 5 – 8 The incidence is estimated to be approximately 1 in 60,000 pregnancies. 9 , 10 The disease shows a worldwide distribution 2 , 5 , 6 , 8 , 11 , 12 and no differences in ethnicity. 13 The median age of affected women varies between 17 and 41 years, with a median age of onset around 26–32 years.…”

“… 13 The median age of affected women varies between 17 and 41 years, with a median age of onset around 26–32 years. 11 , 14 – 16 …”

“…PG mainly affects multiparous women in their second or third trimester of pregnancy, but onset in the first trimester or postpartum period is also reported. 2 , 11 , 12 , 14 , 16 – 19 In a case series from the UK of women with PG including 117 pregnancies, the time of onset of PG ranged from 5 weeks of gestation to 35 days postpartum. Of the 117 pregnancies, 21 (17.9%) presented in the first trimester, 40 (34.2%) presented in the second trimester, and 40 (14.2%) presented in the third trimester, whereas in 16 (13.7%) the eruption began postpartum.…”