Pemphigoid gestationis: current perspectives

Sävervall, Christine; Sand, Freja Lærke; Thomsen, Simon Francis

doi:10.2147/ccid.s128144

Cited by 51 publications

(72 citation statements)

References 48 publications

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“…The disease shows a worldwide distribution and no differences in ethnicity. General population studies on the epidemiology of PG are small 4. The rash is characterized by pruritic papular and vesiculobullous eruptions that typically involve the abdomen and extremities.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to distinguish this disease from other pregnancy-associated dermatoses because of the high rate of recurrence with more severe symptoms in later pregnancies 1,4. Typically fetuses are unaffected; however, in less than 5% of cases they can contract transient skin lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Typically fetuses are unaffected; however, in less than 5% of cases they can contract transient skin lesions. While fetal outcome is generally good, there is increased risk for intrauterine growth restriction as well as preterm labor 2,4. Diagnosis is made either clinically, by skin biopsy with direct immunofluorescence (showing linear deposits of complement along the basement membrane), or elevated BP180 antibody levels.…”

Section: Discussionmentioning

confidence: 99%

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Pemphigoid Gestationis

Kukkamalla

Bayless

2019

Clinical Practice and Cases in Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pemphigoid Gestationis

Kukkamalla

Bayless

2019

Clinical Practice and Cases in Emergency Medicine

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“…GP frequency correlates with HLA DR3 and HLA DR4 haplotypes. The pathogenesis of GP is characterized by deposition of autoantibodies directed against two hemidesmosomal proteins, BP180 and BP230, within the dermoepidermal junction, resulting in the formation of bullae and skin erosions (14). The onset of the disease in the periumbilical region then spread to the gluteal, trunk and extremities.…”

Section: Discussionmentioning

confidence: 99%

Specific and Non-spesicific Dermatoses of Pregnancy in the Emergency Department

Bilgili¹,

Bilvanisi²,

Bilgili³

et al. 2019

Eastern J Med

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During pregnancy, skin lesions can occur as a result of immunological, endocrine, metabolic and vascular changes (1). Due to the presence of hormone receptors in the skin and its related structures, several changes can be observed in eccrine and apocrine units, the pilosebaceous unit and the vascular system. Those changes can be related to protein and steroid structures released by the fetoplacental unit as well as increased endocrine gland activities on the part of the hypophysis, thyroid and adrenal glands (2). Pregnancy-related skin changes include pregnancyinduced physiological skin changes, specific dermatosis of pregnancy and nonspecific dermatosis (3). Herein, we investigated an incidence and features of specific dermatosis of pregnancy, and nonspecific dermatosis in pregnant women who were admitted to the emergency department for skin related complaints. Materials and Methods We enrolled 99 pregnant patients who were admitted to the emergency department between January 2010 and November 2011. We retrospectively collected clinical and laboratory findings, diagnoses, administered treatments, and admission rates from the medical charts. The study protocol was carried out in accordance with the Helsinki Declaration as revised in 2013. The study protocol was approved by the Van Yuzuncu Yil University, Faculty of Medicine of local ethics committee (approval number: 5/ 2014). Clinical and laboratory findings including complete blood count, comprehensive metabolic panel, Creactive protein test, urinalysis, skin biopsy, and

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“…Pemphigoid gestationis (PG) is a rare dermatosis that occurs during pregnancy with a reported incidence rate between 0.5 and 2 per million/year (71–73). It usually affects pregnant women during the third trimenon and, less commonly, during the second trimenon or post-partum period (28, 74, 75). When occurring during the first pregnancy, the disease reoccurs in following pregnancies in 90% of the cases.…”

Section: Introductionmentioning

confidence: 99%

Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases

et al. 2019

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Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads to inflammation at the respective binding site and degradation of these structures, resulting in the separation of the affected skin layers. Clinically, blistering, erythema and lesions of the skin and/or mucous membranes can be observed. Based on the localization of the autoantigen, AIBDs can be divided into pemphigus (intra-epidermal blistering diseases) and pemphigoid diseases (sub-epidermal blistering diseases), respectively. Although autoantigens have been extensively characterized, the underlying causes that trigger the diseases are still poorly understood. Besides the environment, genetic factors seem to play an important role in a predisposition to AIBDs. Here, we review currently known genetic and immunological mechanisms that contribute to the pathogenesis of AIBDs. Among the most commonly encountered genetic predispositions for AIBDs are the HLA gene region, and deleterious mutations of key genes for the immune system. Particularly, HLA class II genes such as the HLA-DR and HLA-DQ alleles have been shown to be prevalent in patients. This has prompted further epidemiological studies as well as unbiased Omics approaches on the transcriptome, microbiome, and proteome level to elucidate common and individual genetic risk factors as well as the molecular pathways that lead to the pathogenesis of AIBDs.

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Pemphigoid gestationis: current perspectives

Cited by 51 publications

References 48 publications

Pemphigoid Gestationis

Pemphigoid Gestationis

Specific and Non-spesicific Dermatoses of Pregnancy in the Emergency Department

Genetics and Omics Analysis of Autoimmune Skin Blistering Diseases

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