Retrospective Analysis of Pattern of Cutaneous Adverse Drug Reactions in Tertiary Hospital of Pauri Garhwal

Dimri, Deepak; Rs, Raina; Thapliyal, Somesh; Thawani,

doi:10.7860/jcdr/2016/16938.7736

Cited by 14 publications

(22 citation statements)

References 18 publications

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“…Altogether we observed 18 different types of cutaneous adverse drug reactions. Exanthematous type was the commonest type of reaction observed in our study which is in accordance to the finding of several other authors 4,8,12,[15][16][17] . Fixed drug eruption was the second most common drug eruption seen in our study similar to the finding of Patel RM et al 18 .…”

Section: Discussionsupporting

confidence: 93%

“…Majority of our patients were in the age group of 21 to 40 years which is comparable with other studies 7,12 . Lesser number of CADRs were observed in pediatric age group (<14 years) in our study (10%), which is similar to the findings of Dimri D et al 12 and Gonzalez Martin G et al 13 .…”

Section: Discussionsupporting

confidence: 91%

“…Antimicrobials was the commonest drug category of drug involved in CADR observed by several authors 8,12,16 . Antibiotic was the most common cause of CADR in our study.…”

Section: Discussionmentioning

confidence: 98%

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Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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Background: Cutaneous adverse drug reactions (CADRs) range from minor reactions to several life threatening complications. Objectives: To study the clinical spectrum of cutaneous adverse drug reactions, determine the causative drugs responsible for the reactions and to assess the preventability.Methods: The study was carried out in the Department of Dermatology of Gandaki Medical College Teaching Hospital from June 2011 to June 2015. All the patients attending the Dermatology Outpatient Department and the patients admitted in the wards with suspected cutaneous adverse drug reactions to systemic drugs were included in the study. A detailed clinical history, including the history of drug intake was noted. Each case was assessed for its causality by using the WHO definitions. Data analysis was done using SPSS software.Results: There were 102 patients in total. The mean age of the patient was 32 ±15.7 years. Maximum patients belonged to the 21 to 30 years age group. There were 59 female patients and 43 male patients. Severe type of cutaneous adverse drug reactions was noted in 7.8% of patients. Antibiotics were responsible for most of the cutaneous adverse drug reactions. Cefixime was the most commonly incriminated drug. Exanthematous drug reaction was the most common type seen in 45%. Stevens-Johnson syndrome was the commonest type noted among the serious adverse drug reactions. Drug preventability was noted in 6% of patients.Conclusions: The commonest type of CADR noted was exanthematous type. Antibiotics were the commonest drug group involved in CADR. Six percent of CADR were preventable. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 21-26

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

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Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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“…The total cases of adverse cutaneous drug reactions analyzed in the period of 3 years were 564 (40.31% of total reactions). 3 Males showed slight predominance in this study which coincided with Agrawal et al, and not similar to Dimri et al 16,17 Most common age-group was that of adults (13-60 years) (74.82%) which was similar to Chauhan VS study (47%). 18 This is because majority of patients coming to OPD or admitted to wards were between 20-50 age group which coincides with high Indian population in this age group.…”

Section: Discussionsupporting

confidence: 82%

A surveillance study of cutaneous adverse drug reactions in a tertiary care teaching hospital in India

Badar¹,

Parulekar²,

Garate³

2018

Int J Basic Clin Pharmacol

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Background: Skin is one of the most common targets of adverse drug reactions (ADRs) The practice of pharmacovigilance all over the world is 5% whereas in India, it is below 1%. Hence, the purpose of our study is to monitor and analyze the suspected cutaneous adverse drug reactions (ACDRs) reported at our tertiary care teaching hospital, to characterize the nature and predictability, severity and preventability of ACDRs and identify most common drugs causing cutaneous ACDRs so that they can be given cautiously and with keen surveillance.Methods: An observational study was conducted in patients attending outpatient and inpatient department for a period of 3 years. All ACDRs of patients were referred by health care professionals and the diagnosis were made by concern doctors. The recorded data was filled in the ADR form obtained from pharmacovigilance program of India (2011) and Central Drug Standard Control Organization (CDSCO) website.Results: Out of 1399 ADR reports analyzed, 564 reports (40.31%) were of ACDRs, female to male ratio was 0.85. Redness (44.32%) was most common symptom, followed by itching (44.14%) and rash (19.14%). Antimicrobials (43.97%), NSAIDS (21.63%), Anti-retroviral therapy drugs (13.65%) were common groups. As per WHO-UMC causality classification, modified Hartwig and Siegel severity scale, Thornton and Schumock preventability scale, ACDRs were probable, mild and possibly preventable respectively.Conclusions: Effective ADR monitoring plays a role in safety of medicines. So, awareness regarding early diagnosis and prompt treatment should be created among the health care professionals and reporting of ACDRs should be regularly practiced by all the departments.

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“…In a recent review, Adler et al summarize three major algorithms to assess drug causality in SCARs: the Naranjo scale, the Algorithm of Drug Causality for Epidermal Necrolysis (ALDEN) for SJS/TEN, the European Registry of Severe Cutaneous Adverse Reactions to Drugs (RegiSCAR) criteria, the Japanese group of Severe Cutaneous Adverse Reactions to Drugs (SCAR‐J) criteria for DRESS, the European Study of Severe Cutaneous Adverse Reactions scoring system for AGEP . In literature, the rate of hospital admissions for SCARs is reported to be from 0.3 up to 3.6/1000 and many epidemiological studies focused on SCARs analysed incidence, demographic characteristics of patients, possible triggers and mortality rate in a hospital setting . In most of them, diagnosis was based on clinical features and history of drug administration, without allergy investigation, except for a few .…”

Section: Introductionmentioning

confidence: 99%

Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9‐year experience in a tertiary care paediatric hospital setting

Liccioli

Mori

Parronchi

et al. 2019

Clin Experimental Allergy

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Background: Severe cutaneous adverse reactions (SCARs) are delayed-type hypersensitivity reactions to drugs including as follows: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and Acute Generalized Exanthematous Pustulosis (AGEP). Incidence, triggers and management of SCARs have not been investigated in large-scale epidemiological studies on children.Objective: The aim of our study was to collect epidemiological, clinical and aetiological data from children with SCARs referred to our tertiary care paediatric hospital of Florence.Methods: From 2010 to 2018 charts of children with diagnosis of SCAR were reviewed, and data collected during the acute phase and/or the subsequent allergy evaluation. Patients underwent patch tests, intradermal tests and lymphocyte transformation tests. All children were investigated for infectious diseases.Results: Incidence of SCARs in hospitalized children was 0.32% over a 9-year period.Fifty-four children were enrolled (31 M; 23 F; median age 6.5 years): 17 cases of DRESS, 30 SJS, 3 TEN, 2 AGEP, 1 linear immunoglobulin A bullous disease (LABD) and 1 pemphigus. Twenty-eight out of 54 patients underwent drug allergy investigations, and 50% of them resulted positive. Combining clinical history and results of allergy work-up, 74% SCARs seem to be caused by drugs, 18.6% by both drugs and infections, 3.7% by infections, and 3.7% remained idiopathic. No deaths occurred. Conclusions:In this study, SCARs incidence is in line with literature data. Drugs were most commonly the leading cause. Management of SCARs requires cooperation among professional figures for an early diagnosis and a prompt treatment. Mortality rate seems to be lower in children. K E Y W O R D Sacute generalized exanthematous pustulosis, aetiopathogenesis, children, drug reaction with eosinophilia and systemic symptoms, hypersensitivity drug reactions, lymphocyte | 65

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Retrospective Analysis of Pattern of Cutaneous Adverse Drug Reactions in Tertiary Hospital of Pauri Garhwal

Cited by 14 publications

References 18 publications

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

A surveillance study of cutaneous adverse drug reactions in a tertiary care teaching hospital in India

Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9‐year experience in a tertiary care paediatric hospital setting

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