Retrospective analysis of oral cavity squamous cell carcinoma treated with surgery and adjuvent radiotherapy

Sharma, Mohit; Deshpandey, Abhinav; Gupta, Neeta; Patel, Madhabhai M.

doi:10.18203/2320-6012.ijrms20160683

Cited by 5 publications

(10 citation statements)

References 16 publications

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“…LVI is a predictor of the progression of advanced-stage disease, as its presence is attributed to aggressive tumor behavior in head and neck cancer ( 109 ). The presence of LVI indicates that a significant amount of neoplastic cells have been accessing the lymphovascular flow to form tumor emboli, consequently increasing the chance of LNM, distant metastasis and recurrence ( 16 , 110 , 111 ). The present study demonstrated that the presence of LVI was significantly associated with LNM (OR, 8.96; P<0.0001).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

et al. 2022

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The incidence profile of oral squamous cell carcinoma (OSCC) has not previously been comprehensively reported in Indonesia. The present study aimed to identify clinicopathological characteristics of patients with OSCC according to sex and age, to analyze histological differentiation patterns specific to tumor subsites, to highlight the role of lymphovascular invasion (LVI) in metastasis, and to develop a model to predict advanced stage and margin invasion. A retrospective cross-sectional study was performed using 581 medical records and pathological specimens from cancer registry data in the Dr Cipto Mangunkusumo Hospital (Jakarta, Indonesia), between January 2011 and December 2020. Clinicopathological characteristics were analyzed using parametric and non-parametric tests. Multivariate logistic regression analyses were performed for eligible parameters, identified using bivariate analysis, to predict advanced stage and margin invasion. Calibration of the prediction model was evaluated using the Hosmer-Lemeshow test, its discrimination value assessed using the receiver operating characteristic and area under the receiver operating characteristic curve (AUC). Sex-specific patterns in tumor subsites and differences in clinical staging according to age were demonstrated in the patients with OSCC. The proportion of well-differentiated cases was significantly higher in most tumor subsites, except in the buccal mucosa (more moderately differentiated cases) and floor of the mouth (well and moderately differentiated cases being equal). LVI was significantly associated with nodal metastasis but not distant metastasis. Multivariate analysis demonstrated that age ≤45 years [odds ratio (OR), 2.26] and LVI (OR, 8.42) predicted patients having advanced-stage OSCC among general populations (AUC, 0.773); however, LVI (OR, 8.28) was the sole predictor of advanced stage amongst young patients (AUC, 0.737). Margin invasion was predicted solely by tumor subsite, including mouth not otherwise specified (OR, 3.04) and palate (OR, 6.13), in the general population (AUC, 0.711). Furthermore, margin invasion was predicted by the palate subsite (OR, 38.77) and LVI (OR, 11.61) in young patients (AUC, 0.762). Investigating young patients thoroughly when finding SCC in the mouth and palate, and assessing LVI, especially among young patients, is critical to prevent advanced staging and margin invasion.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

et al. 2022

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“…Lymph node metastasis, even in early-stage tumours (T1/T2), is high and usually delineates between 27% - 40% due to the rich networks of lymphatics in the oral cavity [14-15]. Distant metastasis was reported to occur in 5% - 25%, most commonly in the extracapsular spread, Uncontrolled locoregional and N-stage diseases (especially N2/N3) are a very strong indicator of systemic spread [15]. BMSCC has shown to have distant metastasis most often in lungs and less commonly involving the heart, neck, thyroid, and vertebra [16].…”

Section: Discussionmentioning

confidence: 99%

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review

Gayathri

Gopal

Vardhan

et al. 2018

Cureus

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Oral squamous cell carcinoma is a leading cause of mortality due to late diagnosis in India and most other developing countries. Buccal squamous cell carcinoma is almost always preceded by premalignant conditions that include leukoplakia, erythroplakia, oral lichen planus, and submucous fibrosis of the oral cavity. Hence, these patients warrant regular screening by oral health care professionals and proper monitoring for any dysplastic changes. Implementing social awareness about early signs and symptoms, as well as education on self-oral screening methods so as to avoid the risk of late presentation of oral squamous cell carcinoma, should be made mandatory for such individuals to prevent further complications.

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“…Such high-risk habits are highly prevalent in India and throughout the Indian subcontinent and South-East Asia. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…Such high-risk habits are highly prevalent in India and throughout the Indian subcontinent and South-East Asia. [8] The combination chemotherapy using methotrexate, bleomycin, and cisplatin gave a significantly high rate of tumor regression, with a significant number of patients showing either CR or PR. These results are comparable by to those done by other researchers separately using these drugs.…”

Section: Discussionmentioning

confidence: 99%

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Kumar¹,

Biswas

Sarkar

et al. 2017

Indian J Med Paediatr Oncol

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Context:Cancers of the buccal mucosa (CaBM) predominate in India with late- stage diagnosis and poor survival, necessitating optimal management. Aim: Our study aimed at testing the efficacy of combination neoadjuvant chemotherapy (NACT) using cisplatin (CIS), bleomycin (BL) and methotrexate (MTX) for reducing tumour volume prior to surgery.Methodology:Patients with advanced CaBM (stage III, IV, n = 100) were administered 6 rounds of NACT with CIS, BL and MTX. Responses, toxicity and 6-month follow-up was monitored statistically to determine persistence of response.Results:A significant number of patients showed objective response as either complete or partial tumour regression with subjective response as reduced trismus, pain, salivation and foul odour. Moreover, there was mild associated toxicity and tumour regression continued in most patients even after 6-month follow-up.Conclusion:Our study indicates that NACT with CIS, BL and MTX offers a good therapeutic alternative in terms of significant objective and subjective responses, low toxicity, affordable costs and persistent responses.

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Retrospective analysis of oral cavity squamous cell carcinoma treated with surgery and adjuvent radiotherapy

Cited by 5 publications

References 16 publications

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

Clinicopathological characteristics predicting advanced stage and surgical margin invasion of oral squamous cell carcinoma: A single‑center study on 10 years of cancer registry data

Tooth and Advanced Oral Submucous Fibrosis Obscuring Buccal Squamous Cell Carcinoma: A Case Report and Literature Review

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

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