Retrospective analysis of live birth prevalence of children with Down syndrome in Denizli, Turkey

Abstract

ABSTRACT. Down syndrome (DS) is the most frequent chromosome abnormality among live births. Its prevalence increases with maternal age, and can be diagnosed by antenatal screening. We examined prevalence variations of DS in Denizli, Turkey, through a retrospective study. Sixteen years of survey data were retrieved from the two main state hospital registries from records between 1994 and 2010. We identified 113 DS live births in Denizli for 16 years. The prevalence of DS was 9.07 per 10,000 live births before the year 2000 and 9.90 after 2000. The prevalence did not change significantly. The population in Turkey is still young; the fertility rate is high in women under 35 years old and prenatal screening programs are extensively applied; for these reasons, the prevalence of DS has remained stable during these 16 years.

Current status of prenatal diagnosis in Cuba: causes of low prevalence of Down syndrome

“…The prevalence of Down syndrome in Cuba is 7 per 10 000 live births, the lowest internationally reported prevalence in a country in which non-invasive screening by the triple test is unavailable. [23][24][25][26][27][28][29] Down syndrome and chromosomal anomalies in general have a low prevalence in Cuba due to several factors.…”

Determination of median values of triple screening test hormones for Kayseri region and their cross-regional comparisons

“…[1,2] The test (also known as second trimester screen test) includes serum biochemistry screening performed between 14 and 20 gestational weeks and is based on generating a congenital disease-specific risk ratio by a program using maternal serum total beta-human chorionic gonadotropin (tβ-hCG), unconjugated estriol (uE3), alpha-fetoprotein (AFP) values and maternal age as input. [3][4][5] As with other biochemical parameters, it is needed to measure the parameters accurately in accordance to terms of laboratory carrying out analyses for reliability of risk results reported in triple screen test. The median values used for calculation can be affected by several factors including population, geographic region, ethnicity, age or smoking.…”

Down Sendromlu Çocuklarda Uyku Apne Sendromu Ve Ağiz Di̇ş Sağliği

“…Anahtar Kelimeler: Down Sendromu, Obstruktif Uyku Apnesi GĠRĠġ Down Sendromu (DS) (Trizomi 21) yeni doğanın mental ve fiziksel retardasyonunu içeren yaygın kromozom anomalilerinden biridir. 1,2 . Görülme sıklığı ortalama 600-700'dür ve toplumlar arasında ciddi farklılıklar göstermez.…”

“…3 Ülkemizde DS'li doğan canlı bebek oranı; Türkiye Özürlüler Araştırması (2002,2011) verilerine göre ortalama 8-10 / 100,00'dur. [2][3][4] (8,9). Ek olarak OUAS teşhis edilen DS'li bireylerde, OUAS'lı sağlıklı bireylere oranla hastalığın seyri daha ağır ilerlemektedir.…”