Current status of prenatal diagnosis in Cuba: causes of low prevalence of Down syndrome

Abstract

Prenatal diagnosis in Cuba has contributed to a significant reduction in chromosomal aberrations. The impact increased because of the demographic trends of the population, the high index of terminations of pregnancy, and the establishment of a network of cytogenetic laboratories throughout Cuba.

Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening

“…The number of born individuals with T21 has been decreasing; however, the incidence has stayed the same even with the introduction of prenatal diagnosis in 2008. Our results on the LB and total incidences are consistent with long-term studies from most EUROCAT regions [3], including Slovenia [13], England and Wales [14], Cuba [10], and Australia [15]. In the USA and Netherlands, by contrast, T21 live birth prevalence has been increasing since the early 1990s [5,16].…”

“…This is the first study to analyze all data on T21 diagnosed both prenatally and postnatally in the 10 year period between January 01, 2005 to December 31, 2015 in Bosnia and Herzegovina. The calculated incidence for the live born DS individuals is 1:999, which is the comparable with the worldwide estimated incidence of DS that is between 1:750 to 1:1100 live births [3,[9][10][11][12]. The number of born individuals with T21 has been decreasing; however, the incidence has stayed the same even with the introduction of prenatal diagnosis in 2008.…”

Aumento de la mortalidad infantil en niños con síndrome de Down: Chile 1997-2013

“…La prevalencia de nacidos vivos con SD es muy variable entre países y depende de la proporción de embarazos en edad materna avanzada (35 o más años) 28,29 , del uso de técnicas de diagnóstico antenatal de malformaciones y anomalías cromosómicas 30,31 y del aborto eugenésico legal [32][33][34] .…”

Estudio de prevalencia en niños recién nacidos con síndrome Down y sus características antropométricas. Hospital Regional de Antofagasta, Chile

“…El síndrome de Down [SD] es una de las patología con mayor incidencia dentro de las etiología genética 1 incluso alcanzando en algunos países cifras cercanas al 76,4% del total de ellas 2 y otras el 47,2% de todas las aberraciones cromosómicas estudiadas 3,4 . En Chile se han realizado algunos estudios en hospitales asociados al ECLAMC (Estudio Colaborativo Latino Americano de Malformaciones Congénitas) con el objeto de determinar la cantidad de niños nacidos con diagnóstico de SD 5 , en ellos se ha descrito que los nacimientos de menores con SD se ha incrementado y entre los factores más frecuentemente referidos, está la edad de la madre.…”