Retrospective analysis of hepatitis B virus chronic infection in 247 patients: clinical stages, response to treatment and poor prognostic factors

Cunha‐Silva, Marlone; Marinho, Fernando A. M.; Oliveira, Paulo; Lopes, Tirzah M.; Sevá‐Pereira, Tiago; Lorena, Sônia Letícia Silva; Almeida, José R.

doi:10.1016/j.bjid.2017.03.019

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…Cirrhosis as a predictor of HBsAg loss remains controversial, considering the long duration of infection prior to loss in most patients. Some included studies reported liver cirrhosis as a factor associated with HBsAg loss (27,47), whereas many others showed no association (62,65,71,73). In addition, while the risk of HCC is clearly ameliorated with HBsAg loss, it is much less so among cirrhotics and patients older than 50 (7).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous loss of surface antigen among adults living with chronic hepatitis B virus infection: a systematic review and pooled meta-analyses

Zhou

Contag

Whitaker

et al. 2019

The Lancet Gastroenterology & Hepatology

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Background-Spontaneous loss of hepatitis B surface antigen (HBsAg), or functional cure, in patients with chronic hepatitis B (CHB) significantly reduces liver-related complications. Differential rates have been suggested by individual studies performed in non-endemic and endemic regions, potentially related to likelihood of spontaneous clearance if CHB was acquired as an adult versus child. We systematically determined a pooled annual rate of HBsAg loss in untreated CHB-infected adults and examined impact of regional endemicity. Methods-Pubmed/EMBASE were searched for observational cohort studies and non-treatment arms of randomized controlled trials (RCTs) reporting proportion of patients with CHB achieving spontaneous HBsAg loss. RCTs were excluded from meta-analyses due to substantial cohort differences. Results were stratified on whether the underlying cohort primarily arose from an endemic, defined as CHB prevalence >2%, or non-endemic region. We explored sources of heterogeneity through univariate meta-regression. Results-Of 4771 screened, 66 studies (11 RCTs, 38 prospective and 17 retrospective cohort studies) met inclusion criteria and 55 were included in meta-analyses with exclusion of RCTs. Spontaneous HBsAg loss occurred in 3489 (7.6%) of 45,975 patients with 341,862 person-years of follow-up. The pooled annual incidence rate of HBsAg loss was 1.13% (0.92-1.36%, I 2 =96%). Rates did not differ by endemicity: 1.13% (0.85-1.45%) in endemic vs 1.29% (0.99-1.62%) in non-endemic cohorts. Meta-regression showed proportion of cohort HBeAg-negative and cohort age were primary contributors to substantial heterogeneity. Conclusion-Globally, spontaneous HBsAg loss occurs infrequently (~1% per year) in treatment-naïve adults with CHB infection. The low and homogeneous rate of HBsAg loss

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Section: Discussionmentioning

confidence: 99%

Spontaneous loss of surface antigen among adults living with chronic hepatitis B virus infection: a systematic review and pooled meta-analyses

Zhou

Contag

Whitaker

et al. 2019

The Lancet Gastroenterology & Hepatology

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“…Transmission of this virus occurs via exchange of bodily fluid such as blood, semen, and perinatal transmission. Hepatitis B has been majorly associated with hepatocellular carcinoma, cirrhosis, and chronic hepatitis, and this makes it identifiable as a major health issue in various developing countries 3 . An increased rate of this disease occurrence has been recorded in regions like East Asia and sub‐Saharan Africa where 5%‐10% of adults in these locations come up with chronic hepatitis infection as compared to other areas 4 …”

Section: Introductionmentioning

confidence: 99%

Studies on the serological markers for hepatitis B virus infection among type 2 diabetic patients

Ndako

Nwankiti

Olorundare

et al. 2021

Clinical Laboratory Analysis

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Background Hepatitis B infection is a public health concern globally. HBV can be associated with type II diabetes mellitus, as HBV outbreaks have been observed among diabetics in healthcare facilities. This study evaluates the prevalence of HBV infection among patients with type II diabetes mellitus. Method A total of one hundred and eighty (180) diabetic patients and one‐hundred non‐diabetics (Controls) were recruited for this study. Structured questionnaires were administered to the consented participants to obtain relevant data. Sera samples obtained were screened using the HBsAg ELISA kit; CTK Biotech, Inc, while the 5 panel kit—rapid diagnostic test, was used to assay for serological markers. Questionnaires were used to obtain relevant information and demographic data. Result Overall prevalence of HBV infection among diabetes patients was 13.3%. Breakdown showed 9 (5.0%) seropositivity was obtained among male subjects compared to 15(8.3%) recorded among the females, P = .834; P < .05. Subjects aged 41‐50 years recorded, 7(3.9%) positivity P = .774; P > .05. Educational status of participants showed 22 (12.2%) positivity among subjects with tertiary level of education P = .032; P < .05). Risk factors considered showed that 5(2.8%).seropositive subjects were alcoholic consumers ( P value = .9711; P > .05). Result among non‐diabetics (Control) subjects showed (4%) seropositivity among the male subjects compared to (5.0%) seropositivity recorded among the female subjects ( P = .739; P > .05). Conclusion There is an indication of higher risk of HBV infection among type 2 diabetic patients when compared to non‐diabetics. There is the need for more research on this area of study, to further validate the association between HBV infection and Diabetes Mellitus.

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“…The predominance of HBeAg negative forms, young adulthood and males were usually found in Sub-Saharan Africa [8]. The predominance of HBeAg negative forms was also found in Asia and Europe but in lower proportions [7,9,10]. In South Asia, a quarter of children with chronic HBsAg were still HBeAg positive during adolescence; the spontaneous loss of HBsAg being faster in Africans where only 10% of them remained HBsAg positive in their thirties [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Biological Profile of Chronic Hepatitis B Infection and Its Predictive Factors According to Liver Histological Activity at the Renaissance Hospital, N’djamena, Chad

Mahamat-Saleh

Moussa

Bolti

et al. 2020

Preprint

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Background: the profile of chronic viral hepatitis B has been little studied in Chad. The factors predictive of the presence of hepatic fibrosis are not well known. The aim of the study was to determine the biological profile of chronic HBsAg carriers according to the new European classification of chronic hepatitis B.Method: This is a prospective cross-sectional study carried out in the gastroenterology outpatient department at the Renaissance Hospital in N’Djamena from January, 2018 to July, 2019. All patients with chronic HBsAg were included and documented for at least one year. Patients with hepatitis C, hepatitis D or HIV are known alcoholic patients and were excluded from the study. The biological profile was determined according to four forms; HBeAg positive chronic infection, HBeAg positive chronic hepatitis, HBeAg negative chronic infection, HBeAg negative chronic hepatitis and HBsAg negative phase. Factors associated with presence of significant liver fibrosis were founded by logistical regression.Results: The average age of the patients were 42.4 years old. The sex ratio was 1.43 in favor of men and a total number of 106 patients were included. The median of the transaminase concentrations were 24 IU/ml (AST) and 21 IU/ml (ALT). 61 patients had HBeAg negative chronic infection (59.8%) and 37 patients had HBeAg negative chronic hepatitis (36.2%). HBeAg positive chronic infection and HBeA positive chronic hepatitis were both seen in 2% of the cases. Significant liver fibrosis was independently associated with the ALT levels (Odds ratio=1.038 [1.009-1.068]; p=0.009).Conclusion: Chronic HBeAg-negative B infection is the main form found in chronic HBeAg-positive carriers. Transaminases are a predictive factor for the presence of hepatic fibrosis.

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Retrospective analysis of hepatitis B virus chronic infection in 247 patients: clinical stages, response to treatment and poor prognostic factors

Abstract: Elevations of viral load and serum alanine aminotransferase may select patients with worse prognosis, especially progression to cirrhosis and hepatocellular carcinoma, which were strongly association with death.

Cited by 10 publications

References 26 publications

Spontaneous loss of surface antigen among adults living with chronic hepatitis B virus infection: a systematic review and pooled meta-analyses

Spontaneous loss of surface antigen among adults living with chronic hepatitis B virus infection: a systematic review and pooled meta-analyses

Studies on the serological markers for hepatitis B virus infection among type 2 diabetic patients

Biological Profile of Chronic Hepatitis B Infection and Its Predictive Factors According to Liver Histological Activity at the Renaissance Hospital, N’djamena, Chad

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