Studies on the serological markers for hepatitis B virus infection among type 2 diabetic patients

Ndako, James A.; Nwankiti, Obinna O.; Olorundare, Joy O.; Ojo, Stephen K.S.; Okolie, Charles E.; Olatinsu, Oludolapo; Dojumo, Victor T.

doi:10.1002/jcla.23464

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A higher seroprevalence of HBsAg 16(5.3%) was observed among pupils aged 10-12, followed by 13(4.3%) among subjects aged 7-9, this finding is however in contrast to the work of Ndako et al [19] where Age distribution of HBV infection recorded 15.0%, sero positivity amongst children aged 5-9.The report of an increase in seroprevalence with age is comparable to a study by Ndako et al [11], in a research conducted among primary school children.…”

Section: Discussioncontrasting

confidence: 85%

Study on Hepatitis B Virus Infection and Risk Factors among Children in a Community, North Central Nigeria

Ndako

Ojo

Fajobi

et al. 2021

JAMB

Self Cite

View full text Add to dashboard Cite

Background: Hepatitis B Virus (HBV) is a worldwide health issue and a source of major concern around the globe. Infections caused by hepatitis B virus pose a major challenge to public health. This study evaluates the prevalence and transmission rate of Hepatitis B Virus infection among children of primary school age at our study location. Method: Three hundred and three (303) volunteer subjects were screened.Structured questionnaire were administered to consenting participants to determine demographic and other risk factors for HBV infection.Samples obtained were analysed using a Laboratory-based immunoassay-HBsAg rapid diagnostic test (RDTs) in lateral flow assays formats. Sera samples obtained were stored at -20oc prior use. Results: Overall result showed that 46 (15.2%) were sero-positive for HBV infection. Considering age factor, Children aged 10 – 12 years showed a higher prevalence of 16(5.3%) [P-value 0.736; (P >0.05)]. Based on gender of subjects screened, a prevalence of 34(11.2%) was recorded among the males subjects compared to females with 12(4.0%) positivity, [(P < 0.05)]. Risk factors on family history recorded 13(4.3%) positivity, considering place of circumcision as risk factors among male subjects; result showed that subjects circumcised using traditional methods recorded 17 (11.7%) positivity. [P-value 0.856 (P>0.05)].Respondents with history of cuts recorded a prevalence of 29(9.6%) positivity; [P-Value 0.362 (P>0.05)] considering enzyme assay of positive subjects, 13 (4.3%) subjects recorded an elevated Alanine transaminases. Conclusion: The transmission rate of HBV infection among the family members was found to be high in this study. This upsurge calls for an urgent vaccination of the population by relevant healthcare providers.

show abstract

Section: Discussioncontrasting

confidence: 85%

Study on Hepatitis B Virus Infection and Risk Factors among Children in a Community, North Central Nigeria

Ndako

Ojo

Fajobi

et al. 2021

JAMB

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, in the 2009 H1N1 influenza pandemic, obesity was also identified as an important risk factor for a poor prognosis [ 27 , 28 ]. In general, a number of reports have documented an association between type 2 diabetes and chronic viral infections ( Table 1 ) [ 29 - 48 ].…”

Section: Coronavirus Disease Other Viral Infections and Obesity-relat...mentioning

confidence: 99%

Infections and immunity: associations with obesity and related metabolic disorders

Ray

Bonorden

Pandit

et al. 2023

JPTM

View full text Add to dashboard Cite

About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathological characteristics such as involvement of the renin-angiotensin-aldosterone system, endothelial injury, and pro-inflammatory cytokine release have been shown to be connected with obesity and associated sequelae such as insulin resistance/type 2 diabetes and hypertension. This pathological connection may explain the severity of COVID-19 in patients with metabolic disorders. Many studies have also reported an association between type 2 diabetes and persistent viral infections. Similarly, diabetes favors the growth of various microorganisms including protozoal pathogens as well as opportunistic bacteria and fungi. Furthermore, diabetes is a risk factor for a number of prion-like diseases. There is also an interesting relationship between helminths and type 2 diabetes; helminthiasis may reduce the pro-inflammatory state, but is also associated with type 2 diabetes or even neoplastic processes. Several studies have also documented altered circulating levels of neutrophils, lymphocytes, and monocytes in obesity, which likely modifies vaccine effectiveness. Timely monitoring of inflammatory markers (e.g., C-reactive protein) and energy homeostasis markers (e.g., leptin) could be helpful in preventing many obesity-related diseases.

show abstract

Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Lontchi-Yimagou

Feutseu

Kenmoe

et al. 2021

Sci Rep

View full text Add to dashboard Cite

A significant number of studies invoked diabetes as a risk factor for virus infections, but the issue remains controversial. We aimed to examine whether non-autoimmune diabetes mellitus enhances the risk of virus infections compared with the risk in healthy individuals without non-autoimmune diabetes mellitus. In this systematic review and meta-analysis, we assessed case-control and cohort studies on the association between non-autoimmune diabetes and viruses. We searched PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Web of Science with no language restriction, to identify articles published until February 15, 2021. The main outcome assessment was the risk of virus infection in individuals with non-autoimmune diabetes. We used a random-effects model to pool individual studies and assessed heterogeneity (I2) using the χ2 test on Cochrane’s Q statistic. This study is registered with PROSPERO, number CRD42019134142. Out of 3136 articles identified, we included 68 articles (90 studies, as the number of virus and or diabetes phenotype varied between included articles). The summary OR between non-autoimmune diabetes and virus infections risk were, 10.8(95% CI: 10.3–11.4; 1-study) for SARS-CoV-2; 3.6(95%CI: 2.7–4.9, I2 = 91.7%; 43-studies) for HCV; 2.7(95% CI: 1.3–5.4, I2 = 89.9%, 8-studies;) for HHV8; 2.1(95% CI: 1.7–2.5; 1-study) for H1N1 virus; 1.6(95% CI: 1.2–2.13, I2 = 98.3%, 27-studies) for HBV; 1.5(95% CI: 1.1–2.0; 1-study) for HSV1; 3.5(95% CI: 0.6–18.3 , I2 = 83.9%, 5-studies) for CMV; 2.9(95% CI: 1–8.7, 1-study) for TTV; 2.6(95% CI: 0.7–9.1, 1-study) for Parvovirus B19; 0.7(95% CI: 0.3–1.5 , 1-study) for coxsackie B virus; and 0.2(95% CI: 0–6.2; 1-study) for HGV. Our findings suggest that, non-autoimmune diabetes is associated with increased susceptibility to viruses especially SARS-CoV-2, HCV, HHV8, H1N1 virus, HBV and HSV1. Thus, these viruses deserve more attention from diabetes health-care providers, researchers, policy makers, and stakeholders for improved detection, overall proper management, and efficient control of viruses in people with non-autoimmune diabetes.

show abstract

Studies on the serological markers for hepatitis B virus infection among type 2 diabetic patients

Cited by 4 publications

References 27 publications

Study on Hepatitis B Virus Infection and Risk Factors among Children in a Community, North Central Nigeria

Study on Hepatitis B Virus Infection and Risk Factors among Children in a Community, North Central Nigeria

Infections and immunity: associations with obesity and related metabolic disorders

Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

Contact Info

Product

Resources

About