Retroreflective‐type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

Zhang, Jian; Liu, Jing; Wang, Limei; Li, Zhiyuan; Yuan, Zhen

doi:10.1002/jbio.201600047

Cited by 21 publications

(20 citation statements)

References 32 publications

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“…Various kinds of electropositive iron and iron oxide nanoparticles have been used as contrast media in combination with ultrasound, CT and magnetic resonance imaging for the clinical diagnosis of human cancers ( 47 , 48 ). In addition, targeted contrast agents are considered to enhance optical coherence tomography and improve the accuracy of CT in the diagnosis of tumor tissue masses ( 49 ). However, although contrast media improve the accuracy of CT to a certain degree, their sensitivity has not been improved in previous studies ( 21 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

et al. 2018

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Esophageal cancer is a malignant tumor with a relatively high invasiveness, metastatic potential and worldwide incidence among human cancers. The majority of patients with esophageal cancer are diagnosed in a late tumor stage due to a lack of advanced and sensitive protocols for the diagnosis of patients with early-stage esophageal cancer. In the current study, contrast-enhanced computerized tomography (CECT) combined with Chitosan-Fe3O4 nanoparticles targeting fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR; CECT-CNFV) were used to diagnose patients with suspected esophageal cancer. A Chitosan-Fe3O4-parceled bispecific antibody targeting FGFR and VEGFR was produced and its affinity to esophageal cancer cells was determined both in vitro and in vivo. A total of 320 patients with suspected esophageal cancer were voluntarily recruited to evaluate the efficacy of CECT-CNFV in the diagnosis of early-stage esophageal cancer. All participants were subjected to CT and CECT-CNFV to detect whether tumors were present in the esophageal area. A Chitosan-Fe3O4 nanoparticles contrast agent was orally administered at 20 min prior to CT and CECT-CNFV. The results demonstrated that CECT-CNFV improved diagnostic sensitivity and provided a novel protocol for the diagnosis of tumors in patients with suspected gastric cancer at an early-stage. Furthermore, the resolution ratio of images was enhanced by CECT-CNFV, which enabled the visualization of tiny tumor nodules in esophageal tissue. Clinical data demonstrated that CECT-CNFV diagnosed 200 patients with suspected early-stage esophageal cancer and 120 patients as tumor free. In addition, CECT-CNFV exhibited higher signal enhancement of tumor nodules than CT, suggesting a higher accuracy and accumulation of nanoparticle contrast agent within the tumor nodules of esophageal tissue. Notably, the survival rate of patients with esophageal cancer diagnosed at an early-stage by CECT-CNFV was higher than the mean five-year survival rate (P<0.01). In conclusion, CECT-CNFV enhanced the sensitivity and accuracy of CT in the diagnosis of early-stage esophageal cancer. Thus, CECT-CNFV may improve the accuracy of CT in the diagnosis of mural enhancement in patients with esophageal cancer.

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Section: Discussionmentioning

confidence: 99%

Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

et al. 2018

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“…In addition, many electropositive iron and iron oxide nanoparticles are used as contrast media and have been reported to be useful in the diagnosis of human cancer in previous clinical trials ( 39 , 40 ). Furthermore, retroreflective-type Janus microspheres have also been reported as a novel contrast agent for enhanced optical coherence tomography ( 41 ). However, these contrast mediums only improve the partial accuracy of CT in a certain degree.…”

Section: Discussionmentioning

confidence: 99%

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Zhang

et al. 2017

Exp Ther Med

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Gastric cancer is one of the most common human tumors worldwide. The biggest bottleneck is a lack of advanced and sensitive protocols for the diagnosis of patients with early-stage gastric cancer. Therefore, more sensitive methods of diagnosing gastric cancer are urgently required to improve survival rates. In this clinical study, contrast-enhanced computed tomography (CECT) with targeting nanoparticles contrast agent (CECT-TNCA) was used to diagnose early-stage gastric cancer. The specific-targeted tyrosine kinase inhibitors of gastric cancer, including platelet-derived growth factor receptor-β, Ret and Kit, were used as TNCAs. A total of 484 patients with suspected gastric cancer were voluntarily recruited to investigate the efficacy of CECT-TNCA in the diagnosis of patients with early-stage gastric cancer. Patients with suspected gastric cancer were subjected CT and CECT-TNCA to detect whether gastric tumors existed. TNCA was orally administered before CT and CECT-TNCA (20 min). Our diagnostic data revealed that CECT-TNCA improved sensitivity and provided a new protocol to diagnose tumors in patients with suspected gastric cancer at the early stage. In addition, imaging using CECT-TNCA enabled the visualization of tiny nodules in the gastric area. CECT-TNCA diagnosed 182 patients with suspected gastric cancer as tumor-free. CECT-TNCA confirmed gastric cancer in 302 patients. Our novel diagnosis indicated significantly (P<0.01) differential signal enhancement in the gastric nodules via CECT-TNCA compared with CT, suggesting higher accuracy and the accumulation of TNCA in tumor nodules in the stomach. Furthermore, survival rates of patients detected by early-diagnosis of CECT-TNCA were significantly higher than the mean five-year survival (P<0.01). In conclusion, our investigations demonstrate that the sensibility and accuracy of CT is improved through combination with liposome-encapsulated nanoparticle contrast agent for the diagnosis of early stage gastric cancer when compared with single CT detection. CECT-TNCA improves the accuracy of CT and diagnostic confidence in assessing mural enhancement in patients with suspected gastric cancer.

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“…Zhang Jian et al used semi-wrapped gold film Janus particles as a reflection contrast agent injected into optically transparent zebrafish, and found that the OCT signal of zebrafish was significantly enhanced [ 62 ]. Similar to spherical mirrors, Janus particles have the ability to reflect light, which can more effectively participate in the optical imaging process than pure metal particles or dielectric particles [ 112 ].…”

Section: Manipulation Of Janus Particlesmentioning

confidence: 99%

Controlled Mechanical Motions of Microparticles in Optical Tweezers

Liu

2018

Micromachines

Self Cite

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Optical tweezers, formed by a highly focused laser beam, have intriguing applications in biology and physics. Inspired by molecular rotors, numerous optical beams and artificial particles have been proposed to build optical tweezers trapping microparticles, and extensive experiences have been learned towards constructing precise, stable, flexible and controllable micromachines. The mechanism of interaction between particles and localized light fields is quite different for different types of particles, such as metal particles, dielectric particles and Janus particles. In this article, we present a comprehensive overview of the latest development on the fundamental and application of optical trapping. The emphasis is placed on controllable mechanical motions of particles, including rotation, translation and their mutual coupling under the optical forces and torques created by a wide variety of optical tweezers operating on different particles. Finally, we conclude by proposing promising directions for future research.

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Retroreflective‐type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

Cited by 21 publications

References 32 publications

Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Controlled Mechanical Motions of Microparticles in Optical Tweezers

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