Retropharyngeal neuroblastoma causing airway obstruction in a newborn—Survival with surgical treatment alone

Yokoya, Susumu; Suda, Toshio; Koyama, Minoru; Yamaguchi, Masayoshi; Kamoshita, Shigehiko; Miyakawa, Koichi; Moriyama, Shinichi

doi:10.1016/s0022-3468(82)80207-8

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…Although there were some cases reported before the 1990s, treatment modalities varied widely, even for the same stage of disease, and may have been related to proximity to vital structures which may have made complete surgical excision difficult. There have been three approaches described for surgical treatment for retropharyngeal NB; transoral [1], transcervical [14], and transhyoidpharyngotomy [4]. In our case, we performed a tracheostomy prior to complete excision transorally.…”

Section: Discussionmentioning

confidence: 96%

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Retropharyngeal neuroblastoma in a neonate: case report and literature review

et al. 2007

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Primary cervical neuroblastoma (NB) in neonates is extremely rare. We treated a 1-day-old male neonate who presented with stridor and feeding difficulty and was subsequently diagnosed with NB of the retropharynx. The tumor was excised in toto transorally, and no metastatic lesions were confirmed. Histopathology and molecular genetic analysis showed poorly differentiated NB with no N-myc amplification, stage I NB. He has had no signs of recurrence or adverse sequelae during 18 months of follow-up. We report our experience and review the literature.

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Section: Discussionmentioning

confidence: 96%

“…Although neuroblastoma (NB) is a relatively common malignancy in childhood, primary cervical NB in neonates is extremely rare [1,2]. We report a neonatal case of retropharyngeal NB whom we treated successfully and review the literature.…”

Section: Introductionmentioning

confidence: 99%

Retropharyngeal neuroblastoma in a neonate: case report and literature review

et al. 2007

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“…The differential diagnosis includes: vascular tumors, cystic hygromas, branchial cysts, cervical neural tube defects, heterotopic neuroglial tissue as well as solid tumors, including teratomas, neuroblastomas, rhabdoid tumors, or sarcomas. Congenital neuroblastoma is also known to occur, but very few cases are of cervical origin 1. Prenatal diagnosis of cervical congenital neuroblastoma has only been described once 2.…”

Section: Discussionmentioning

confidence: 99%

Porous polymer monolith templated by small polymer molecules

Frederic

Talarico³

et al. 2009

Can J Chem Eng

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Porous poly(ethylene glycol) diacrylate (PEGDA) monoliths have been prepared by UV-initiated polymerization of PEGDA oligomer (M n = 700 g/mol). In the mean time, the addition of hydrophobic poly(propylene oxide) (PPO, M n = 725 g/mol) as porogen into an ethanol solution of PEGDA oligomer to form a homogenous mixture, causes a phase separation between PPO and PEGDA following removal of ethanol by UV heating. Porous PEGDA monolith was prepared by immediate heating at 300 • C to remove PPO molecules from the as-synthesized PEGDA/PPO hybrid. The micrometer pores of the PEGDA monolith have relatively concentrated pore size distribution according to the mercury intrusion porosimetry results and field emission scanning electron microscopy (FE-SEM).On a préparé des monolithes poreux de polyéthylène glycol diacrylate (PEGDA) au moyen de la polymérisation déclenchée par des UV d'oligomère de PEGDA (M n = 700 g/mole). Entre-temps, l'ajout d'oxyde de polypropylène hydrophobe (OPP, M n = 725 g/mole) comme agent porogène dans une solution d'éthanol d'oligomère de PEGDA afin de former un mélange homogène cause une séparation de phases entre l'OPP et le PEGDA après l'élimination de l'éthanol par chauffage aux UV. On a préparé le monolithe poreux de PEGDA en ayant recours au chauffage immédiatà 300 • C afin d'éliminer les molécules d'OPP de l'hybride de PEGDA/OPP synthétisé. Les pores du micromètre du monolithe de PEGDA ont une distribution de la taille des pores relativement concentrée selon les résultats de la porosimétrie de l'intrusion de mercure et de la microscopié electroniqueà balayageàémission de champ (CFE-SEM).

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“…True retropha- ryngeal neuroblastomas appear to be exceptionally rare, and in the literature, only 4 observations have been sufficiently documented such that the localization of the neuroblastoma medial to the internal carotid artery could be confirmed. [5][6][7] In retropharyngeal localizations, the pharyngeal compression responsible for respiratory disorders is a constant finding, and cervical palpation reveals no abnormalities (Table). When localized laterally, the cervical mass is palpable and precedes the compressive disorders.…”

Section: Commentmentioning

confidence: 99%

“…There have been no relapses reported, with a follow-up varying from 8 months to 5 years (Table). The patients who were cured by surgical treatment alone 5,7 were operated on before the age of 8 weeks.…”

Section: Commentmentioning

confidence: 99%

Primary Retropharyngeal Neuroblastoma

Godey¹,

Pagot²,

Morandi³

et al. 2000

Arch Otolaryngol Head Neck Surg

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Neuroblastoma is the most frequent extracerebral tumor in infants younger than 1 year. It is most often localized in the abdomen or thorax. A cervical localization is rare, and in the majority of cases, the tumor is located in the lateral region of the neck, lateral to the carotid artery. 1 We describe a newborn boy who presented with difficulty in breathing associated with a retropharyngeal neuroblastoma. A retropharyngeal localization is exceptional, and, to our knowledge, there have been no previous reports in which retropharyngeal neuroblastomas were differentiated from lateral cervical neuroblastomas. Our goal is to emphasize the surgical importance of differentiating retropharyngeal cervical neuroblastomas from laterocervical neuroblastomas and to present their clinical and therapeutic characteristics. REPORT OF A CASEA 6-week-old boy was hospitalized with a 1-week history of progressively worsening inspiratory dyspnea and stridor, without any associated feeding problems. There was no family history of neurocristopathy. The clinical examination and endoscopy with the patient under general anesthesia showed a swelling of the left side of the pharynx, covered with normal mucosa, forcing the larynx forward and descending down into the hypopharynx. The mobility of the larynx was normal. Cervical palpation revealed no abnormalities. A left Horner syndrome and a heterochromia iridis were noted. A lateral cervical radiograph showed a pharyngeal tumor forcing the larynx forward (Figure 1). A cervical computed tomographic (CT) scan revealed a welldefined heterogeneous mass, with a few calcifications, that was in contact with the internal carotid artery and the prevertebral area and was reducing the airway (Figure 2). Blood tests were negative for chorionic gonadotropin ␤, carcinoembryonic antigen, ␣-fetoprotein, neuronspecific enolase, and urinary catecholamines. At the age of 8 weeks, the patient was surgically treated because of increasing difficulty in breathing. A transoral approach was used, and a L-shaped incision in the pharyngeal mucosa was performed. The tumor was well defined. The vascular pedicles of the tumor were electrocoagulated. The excision was macroscopically complete. The pharyngeal mucosa was sutured. The patient underwent extubation on awakening, and no dyspnea was observed.Microscopically, the tumor consisted of small, round and fusiform cells, which were only slightly larger than lymphocytes (Figure 3). They were arranged in irregular sheets separated by fibrovascular strands. In well-preserved areas, the cells were larger, with fewer chromatic nuclei, and arranged in round aggregates. There were no true rosettes. The background was loosely fibrillar. On immunohistochemical studies, the tumor cells expressed neuron-specific enolase and synaptophysin. The histologic diagnosis was neuroblastoma.For 8 days, the patient was fed with a nasogastric tube. A control fiberoscopy at day 8 showed complete healing. Oral feeding was resumed without any problems. Iobenguane sulfate I 123 scintigraphy perfor...

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Retropharyngeal neuroblastoma causing airway obstruction in a newborn—Survival with surgical treatment alone

Cited by 13 publications

References 6 publications

Retropharyngeal neuroblastoma in a neonate: case report and literature review

Retropharyngeal neuroblastoma in a neonate: case report and literature review

Porous polymer monolith templated by small polymer molecules

Primary Retropharyngeal Neuroblastoma

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