Retropharyngeal Ganglioneuroma: A Case Report

Yang, Andrew; Ozsvath, Jessica; Shukla, Pratibha S.; Fatterpekar, Girish M.

doi:10.1111/j.1552-6569.2012.00765.x

Cited by 5 publications

(5 citation statements)

References 12 publications

(15 reference statements)

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“…Increased signal intensity on T2W images is thought to reflect high cellularity and large interstitial volume 11. Linear hypointense striations within the lesion likely correspond to interlacing bundles of Schwann cells and collagen fibres 14. Apart from the calcifications, the imaging features of our case correlate well with those described in the literature.…”

Section: Discussionsupporting

confidence: 73%

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Dias¹,

Rosa²,

Rito³

et al. 2017

BMJ Case Reports

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We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Positron emission tomography-CT did not show relevant metabolic activity, excluding the hypothesis of metastatic nodal disease. Surgical biopsy of the lesion was compatible with ganglioneuroma. Ganglioneuromas are well-differentiated tumours composed of mature sympathetic ganglion cells that account for approximately 1% of spinal and paraspinal tumours. Peripherally, ganglioneuromas are predominantly found in the posterior mediastinum and retroperitoneal space. Only nine ganglioneuromas of the retropharyngeal space have been reported in the English literature since the early 1980s.

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Section: Discussionsupporting

confidence: 73%

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Dias¹,

Rosa²,

Rito³

et al. 2017

BMJ Case Reports

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“…Generally, ganglioneuroma has been considered to occur mainly in children and young adults, and to be most commonly diagnosed between the mean ages of 5.5 to 10 years (4,12,13). However, recent reports suggest that the mean age at diagnosis is 40 to 50 years (2,5,(14)(15)(16)(17). GN is slightly more common in women than in men (1.13:1 to 1.5:1) (1, 4).…”

Section: Discussionmentioning

confidence: 97%

“…the retropharyngeal space as in the case described by Yang et al (1,2). Adrenal location of ganglioneuroma is rare: Linos and co-authors identified approximately 230 of such literature cases (3).…”

Section: Introductionmentioning

confidence: 82%

Report on 5 Cases of Adrenal Ganglioneuromas

Kamińska¹

2014

Acta Endo (Buc)

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Background.Ganglioneuroma (GN) is a rare, benign, neuroblastic tumor. It may arise from the sympathetic plexus or adrenal medulla. Its most common location is the posterior mediastinum (41.5%), while in approximately 21% of patients the tumor is located in the adrenal gland. Median age of adults at diagnosis is approximately 40 to 50 years of age. Since GN is most commonly asymptomatic, the diagnosis is usually accidental, i.e. when radiological examinations are performed due to other indications. This slow-growing tumor can reach a large size. In a small percentage of patients the tumor secretes catecholamines.We present five ganglioneuroma patients, who were hospitalized in our Department from 1993 through 2012. Their mean age was 31 years. In four cases the tumor was located in the adrenal gland and in one -extra-adrenally, which was revealed during surgery. In three out of five presented cases pathological hormone secretion by the tumor was confirmed in laboratory results.

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“…The biggest resected GN assessable through literature research up to now showed a maximum diameter of approximately 23 cm [6] in a 42-year-old patient located solely thoracically [6]. Located most commonly in the posterior mediastinum (41.5%) or retroperitoneally (37.5%), ganglioneuromas can be found in the adrenal glands (21%), in the neck (8%), retropharyngeally, or more rarely in the sella turcica [7][8][9][10]. Computed tomography (CT) or magnetic resonance imaging (MRI) represents the gold standard for diagnosis and estimation of tumor extent.…”

Section: Introductionmentioning

confidence: 98%

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

et al. 2020

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Background Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest, they show neuroendocrine potential; however, most are reported to be hormonally inactive. Nevertheless, complete surgical removal is recommended for symptom control or for the prevention of potential malignant degeneration. Case Report A 30-year-old female was referred to our oncologic center due to a giant retroperitoneal and mediastinal mass detected in computed tomography (CT) scans. The initial symptoms were transient nausea, diarrhea, and crampy abdominal pain. There was a positive family history including 5 first- and second-degree relatives. Presurgical biopsy revealed a benign ganglioneuroma. Total resection (TR) of a 35 × 25 × 25 cm, 2550-g tumor was obtained successfully via laparotomy combined with thoracotomy and partial incision of the diaphragm. Histopathological analysis confirmed the diagnosis. Surgically challenging aspects were the bilateral tumor invasion from the retroperitoneum into the mediastinum through the aortic hiatus with the need of a bilateral 2-cavity procedure, as well as the tumor-related displacement of the abdominal aorta, the mesenteric vessels, and the inferior vena cava. Due to their anatomic course through the tumor mass, the lumbar aortic vessels needed to be partially resected. Postoperative functioning was excellent without any sign of neurologic deficit. Conclusion Here, we present the largest case of a TR of a GN with retroperitoneal and mediastinal expansion. On review of the literature, this is the largest reported GN resected and was performed safely. Additionally, we present the first systematic literature review for large GN (> 10 cm) as well as for resected tumors growing from the abdominal cavity into the thoracic cavity.

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Retropharyngeal Ganglioneuroma: A Case Report

Cited by 5 publications

References 12 publications

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Report on 5 Cases of Adrenal Ganglioneuromas

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma—case report and systematic review of the literature

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