Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Dias, Raquel B.; Rosa, Duarte; Rito, Miguel; Borges, Alexandra

doi:10.1136/bcr-2017-220966

BMJ Case Reports

2017

DOI: 10.1136/bcr-2017-220966

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Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Raquel B. Dias¹,

Duarte Rosa²,

Miguel Rito³

et al.

Abstract: We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Positron emission tomography-CT did not show relevant metabolic activity, excluding the hypothesis of metastatic nodal disease. Surgical biopsy of the lesion was compatible with ganglioneuroma. G… Show more

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Cited by 2 publications

References 19 publications

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Cervical ganglioneuroma mimicking a carotid body tumour

2020

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A 30-year-old woman was referred to the ear, nose and throat clinic by her primary care physician for a 10-year history of an asymptomatic, large, right-sided neck mass. On examination, the patient had a palpable, non-tender, five-by-four centimetre, mobile, right-sided level II neck mass. CT scan with intravenous contrast showed an enhancing mass with multiple fluid cavities, splaying the external carotid and internal carotid arteries, concerning for a carotid body tumour. Patient was then referred to interventional radiology for angiography and embolisation prior to definitive surgical excision. However, when the mass was then excised surgically, final pathology identified the mass as a ganglioneuroma. Patient recovered well postoperatively with some ptosis of the right eye and symptoms consistent with first bite syndrome, treated with conservative measures.

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Cervical ganglioneuroma mimicking a carotid body tumour

2020

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Massive ganglioneuroma of the parapharyngeal space in a pediatric patient: a case report

Jayavelu

Anderson

Low

et al. 2022

Egypt J Otolaryngol

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Background Neuroblastic tumors arise from primitive sympathetic ganglion cells and are the most common extracranial solid tumor of childhood. Ganglioneuroma is the most well-differentiated, benign subtype and comprises less than 1% of all soft tissue tumors. One to 5% of these occur in the head and neck, including the parapharyngeal space. It is uncommon to find a physically detectable, neoplastic parapharyngeal space mass in a child. Case report A 7-year-old boy presented with a painless left neck mass. Imaging revealed a 2.6 × 2.7 × 6.1 cm left parapharyngeal space mass. Fine-needle aspiration suggested a ganglioneuroma. The patient developed compressive symptoms, notably pain, thus the decision was made to surgically resect. The tumor was excised transcervically, preserving the great vessels, phrenic and cranial nerves. Postoperatively, the patient developed a mild ipsilateral Horner’s syndrome, suggesting the mass to be a ganglioneuroma of the sympathetic chain. Conclusions Cervical ganglioneuromas typically present as slow-growing masses that cause compressive symptoms or are found incidentally. Resection is reserved for those with significant symptoms and is often complicated by Horner’s syndrome. In the review of literature, there are 23 reported cases of ganglioneuroma in the head/neck with a median age of 17 years. Eight of these occurred in the para/retropharyngeal spaces. Of these, five presented as an asymptomatic neck mass, two presented with compressive symptoms, and one was discovered incidentally. It is important to consider ganglioneuroma in the workup of pediatric neck masses, even in young children. Asymptomatic masses should be monitored for symptomatic transformation, and excision should be considered.

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Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer

Cited by 2 publications

References 19 publications

Cervical ganglioneuroma mimicking a carotid body tumour

Cervical ganglioneuroma mimicking a carotid body tumour

Massive ganglioneuroma of the parapharyngeal space in a pediatric patient: a case report

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